Sandbox GGC9: Difference between revisions
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== Disease == | == Disease == | ||
Collagen-binding proteins(CBP) such as ECM (Extracellular Matrix) can be degrade via invasive pathogenic breach the basal lamina. Degradation of ECM can leads to major loss of mechanical containment molecules that protects the tissues from further pathogens. Furthermore, the pathogen will then degrade the interstitial space and connective tissues via ECM degrading proteases and/or the surface-bound plasminogen and matrix metalloprotein from the host. The adhesion of bacterial pathogen such as ''Staphylococcus aureus'' this particular adhesion calls "Collagen Hug". | Collagen-binding proteins(CBP) such as ECM (Extracellular Matrix) can be degrade via invasive pathogenic breach the basal lamina. Degradation of ECM can leads to major loss of mechanical containment molecules that protects the tissues from further pathogens. Furthermore, the pathogen will then degrade the interstitial space and connective tissues via ECM degrading proteases and/or the surface-bound plasminogen and matrix metalloprotein from the host. The adhesion of bacterial pathogen such as ''Staphylococcus aureus'' this particular adhesion calls "Collagen Hug", where CNA wraps around the collagen and further anchoring the bacteria . | ||
== Structural highlights == | == Structural highlights == | ||
