Sandbox GGC5: Difference between revisions
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== Relevance == | == Relevance == | ||
There is a lot of research going into the development of inhibitors of this enzyme. There are a few that are already known. Some very effective inhibitors are known as pyridinyl | There is a lot of research going into the development of inhibitors of this enzyme. There are a few that are already known. Some very effective inhibitors are known as pyridinyl imidazole inhibitors because they resemble ATP, and are able to competitively inhibit the enzyme. ATP is normally bound at the active site to phosphorylate the molecule, and if it can't occupy that space the p38 MAPK never gets activated, and can't transmit inflammatory signals downstream. | ||
== Structural highlights == | == Structural highlights == | ||
