2hb1: Difference between revisions

Line 4:

|PDB= 2hb1 |SIZE=350|CAPTION= <scene name='initialview01'>2hb1</scene>, resolution 2.0Å

|SITE=

|LIGAND= <scene name='pdbligand=512:4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACID'>512</scene>

|LIGAND= <scene name='pdbligand=512:4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC+ACID'>512</scene>

|ACTIVITY=

|GENE= PTPN1, PTP1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])

|DOMAIN=

|RELATEDENTRY=[[2h4g|2H4G]], [[2h4k|2H4K]]

|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hb1 OCA], [http://www.ebi.ac.uk/pdbsum/2hb1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hb1 RCSB]</span>

}}

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==Overview==

A series of monocyclic thiophenes was designed and synthesized as PTP1B inhibitors. Guided by X-ray co-crystal structural information and computational modeling, rational design led to key interactions with Asp48 and improved inhibitory potency against PTP1B.

~~==Disease==~~

Known diseases associated with this structure: Abdominal body fat distribution, modifier of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176885 176885]], Insulin resistance, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176885 176885]]

==About this Structure==

Line 28:

[[Category: Wan, Z K.]]

[[Category: Xu, W.]]

~~[[Category: 512]]~~

[[Category: protein-inhibitor complex]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu~~ Mar ~~20 17~~:14:51 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:27:58 2008''

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@@ Line 4: / Line 4: @@
 |PDB= 2hb1 |SIZE=350|CAPTION= <scene name='initialview01'>2hb1</scene>, resolution 2.0&Aring;
 |SITE=
-|LIGAND= <scene name='pdbligand=512:4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACID'>512</scene>
+|LIGAND= <scene name='pdbligand=512:4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC+ACID'>512</scene>
 |ACTIVITY=
 |GENE= PTPN1, PTP1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+|DOMAIN=
+|RELATEDENTRY=[[2h4g|2H4G]], [[2h4k|2H4K]]
+|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hb1 OCA], [http://www.ebi.ac.uk/pdbsum/2hb1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hb1 RCSB]</span>
 }}
@@ Line 14: / Line 17: @@
 ==Overview==
 A series of monocyclic thiophenes was designed and synthesized as PTP1B inhibitors. Guided by X-ray co-crystal structural information and computational modeling, rational design led to key interactions with Asp48 and improved inhibitory potency against PTP1B.
-==Disease==
-Known diseases associated with this structure: Abdominal body fat distribution, modifier of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176885 176885]], Insulin resistance, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176885 176885]]
 ==About this Structure==
@@ Line 28: / Line 28: @@
 [[Category: Wan, Z K.]]
 [[Category: Xu, W.]]
-[[Category: 512]]
 [[Category: protein-inhibitor complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:14:51 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:27:58 2008''