Sandbox GGC10

Human Pepsin

spinqualitylabelsall models Human Pepsin Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Pepsin is considered a powerful enzyme found in the stomach of humans and other animals. It helps breakdown and digest proteins into small peptides like meat, seeds, eggs, or dairy products. It is produced by the human gastric mucosa. Pepsin is in complex with pepstatin. It is a very important enzyme, hence one of the first enzymes to be discovered. Function When eating, all your senses are functioning. The digestive system is preparing for the incoming food. After the eating process is complete, the final step is a signal in the stomach that stimulates the medula ablongada. Then, that signals the body to allow the hormone gastrin to work (hormone that inhibits the stomach to release its gastric juices). Gastric juice is converted pepsinogen into pepsin by removing some amino acids. Pepsin then will do its job by aiding to digest what been intake. Structural highlights The region of the pepstatin molecule The region of the pepstatin molecule the residues shown. Ala,Iva, and residues as well as Sta terminal are low on density. They must generate new conformations since the model can't fit View of active sites A protein inhibitor forms an extended conformation with the first hydroxyl oxygen located in the active sites between carboxyl groups Asp 32 and Asp 215 View of residues Val 1- Leu 6, Asp 149- Val 184, and Gln 308-Ala 326 The structure of Human Pepsin is similar to a serine Endoproteinase with molecular weight of 35 kd. the structure is divided into 3 domains. The main domain includes 6 stranded antiparallel beta sheet that helps as a backbone to the active site region. It is comprisedThe N-terminal is also composed of residues

References

https://onlinelibrary.wiley.com/doi/epdf/10.1002/pro.5560040516?referrer_access_token=ZyEVxvIcTcmK5L-vwA_P2k4keas67K9QMdWULTWMo8PQPfTnSk44hq4jBFsrHa9ydjFbMYZrHWbY_9SWvlJek7YeLttGlVWslX2Nvc9rYhwoytl58c9enHGXzQqZutfC