Sandbox Reserved 1449: Difference between revisions

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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.

Opioid receptors are G-protein coupled receptors (GPCR), which bind endogenous opioid peptide neurotransmitters (such as enkephalins and endorphins) and exogenous synthetic opiate drugs (such as morphine, codeine, and heroin) as ligands to hinder pain-signaling in the brain, peripheral nerves, and digestive tract. μ-opioid receptors are one of the four major classes of opioid receptors, which also includes δ-opioid receptors, κ-opioid receptors, and nociceptin opioid receptors. The μ-opioid receptor MOR-1 is expressed by the gene OPRM1 in vertebrates. <ref ~~name= "Article 1"~~ >~~Pasternak, G. W., and Y.-X. Pan. “Mu Opioids and Their Receptors: Evolution of a Concept.” Pharmacological Reviews, vol. 65, no. 4, 2013, pp. 1257–1317., doi~~:10.1124/pr.112.007138. </ref>. MOR-1 has important implications as a target for pain relievers as well as a treatment for drug abuse. ~~<ref>DOI: 10.1124/pr.112.007138</ref>~~

Opioid receptors are G-protein coupled receptors (GPCR), which bind endogenous opioid peptide neurotransmitters (such as enkephalins and endorphins) and exogenous synthetic opiate drugs (such as morphine, codeine, and heroin) as ligands to hinder pain-signaling in the brain, peripheral nerves, and digestive tract. μ-opioid receptors are one of the four major classes of opioid receptors, which also includes δ-opioid receptors, κ-opioid receptors, and nociceptin opioid receptors. The μ-opioid receptor MOR-1 is expressed by the gene OPRM1 in vertebrates. <ref>DOI: 10.1124/pr.112.007138</ref> MOR-1 has important implications as a target for pain relievers as well as a treatment for drug abuse.

== Structural highlights ==

Sandbox Reserved 1449: Difference between revisions

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 You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
-Opioid receptors are G-protein coupled receptors (GPCR), which bind endogenous opioid peptide neurotransmitters (such as enkephalins and endorphins) and exogenous synthetic opiate drugs (such as morphine, codeine, and heroin) as ligands to hinder pain-signaling in the brain, peripheral nerves, and digestive tract.  μ-opioid receptors are one of the four major classes of opioid receptors, which also includes δ-opioid receptors, κ-opioid receptors, and nociceptin opioid receptors.  The μ-opioid receptor MOR-1 is expressed by the gene OPRM1 in vertebrates. <ref name= "Article 1" >Pasternak, G. W., and Y.-X. Pan. “Mu Opioids and Their Receptors: Evolution of a Concept.” Pharmacological Reviews, vol. 65, no. 4, 2013, pp. 1257–1317., doi:10.1124/pr.112.007138. </ref>.  MOR-1 has important implications as a target for pain relievers as well as a treatment for drug abuse. <ref>DOI: 10.1124/pr.112.007138</ref>
+Opioid receptors are G-protein coupled receptors (GPCR), which bind endogenous opioid peptide neurotransmitters (such as enkephalins and endorphins) and exogenous synthetic opiate drugs (such as morphine, codeine, and heroin) as ligands to hinder pain-signaling in the brain, peripheral nerves, and digestive tract.  μ-opioid receptors are one of the four major classes of opioid receptors, which also includes δ-opioid receptors, κ-opioid receptors, and nociceptin opioid receptors.  The μ-opioid receptor MOR-1 is expressed by the gene OPRM1 in vertebrates. <ref>DOI: 10.1124/pr.112.007138</ref> MOR-1 has important implications as a target for pain relievers as well as a treatment for drug abuse.
 == Structural highlights ==