5mh5: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5mh5 is ~~ON HOLD~~ ~~until Paper Publication~~

==D-2-hydroxyacid dehydrogenases (D2-HDH) from Haloferax mediterranei in complex with 2-keto-hexanoic acid and NADP+ (1.4 A resolution)==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5mh5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MH5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MH5 FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7N5:2-Ketohexanoic+acid'>7N5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mh5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mh5 OCA], [http://pdbe.org/5mh5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mh5 RCSB], [http://www.ebi.ac.uk/pdbsum/5mh5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mh5 ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/DDH_HALMT DDH_HALMT]] Catalyzes the stereospecific NAD(P)H-dependent reduction of 2-ketocarboxylic acids into the corresponding D-2-hydroxycarboxylic acids. Can use both NADPH or NADH as reductant, displaying a marked preference for NADPH over NADH. Shows a broad substrate specificity, although it displays a marked preference for the 2-ketocarboxylic acids having an unbranched chain of 4-5 carbon atoms.<ref>PMID:17049749</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Baker, P J]]

[[Category: Bisson, C]]

[[Category: Ferrer, J]]

[[Category: Harding, S E]]

[[Category: Perez, J Domenech]]

[[Category: Pramanpol, N]]

[[Category: Rice, D W]]

[[Category: Chiral specificity]]

[[Category: D-2-hydroxyacid dehydrogenase]]

[[Category: Halophile]]

[[Category: Oxidoreductase]]

[[Category: Reaction mechanism]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5mh5 is ON HOLD  until Paper Publication
+==D-2-hydroxyacid dehydrogenases (D2-HDH) from Haloferax mediterranei in complex with 2-keto-hexanoic acid and NADP+ (1.4 A resolution)==
+<StructureSection load='5mh5' size='340' side='right' caption='[[5mh5]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5mh5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MH5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MH5 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7N5:2-Ketohexanoic+acid'>7N5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mh5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mh5 OCA], [http://pdbe.org/5mh5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mh5 RCSB], [http://www.ebi.ac.uk/pdbsum/5mh5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mh5 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/DDH_HALMT DDH_HALMT]] Catalyzes the stereospecific NAD(P)H-dependent reduction of 2-ketocarboxylic acids into the corresponding D-2-hydroxycarboxylic acids. Can use both NADPH or NADH as reductant, displaying a marked preference for NADPH over NADH. Shows a broad substrate specificity, although it displays a marked preference for the 2-ketocarboxylic acids having an unbranched chain of 4-5 carbon atoms.<ref>PMID:17049749</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Baker, P J]]
+[[Category: Bisson, C]]
+[[Category: Ferrer, J]]
+[[Category: Harding, S E]]
+[[Category: Perez, J Domenech]]
+[[Category: Pramanpol, N]]
+[[Category: Rice, D W]]
+[[Category: Chiral specificity]]
+[[Category: D-2-hydroxyacid dehydrogenase]]
+[[Category: Halophile]]
+[[Category: Oxidoreductase]]
+[[Category: Reaction mechanism]]