5yms: Difference between revisions
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==Structural basis of glycan specificity and identification of a novel glycan binding cavity in human P[19] rotavirus== | |||
<StructureSection load='5yms' size='340' side='right' caption='[[5yms]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5yms]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YMS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YMS FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yms OCA], [http://pdbe.org/5yms PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yms RCSB], [http://www.ebi.ac.uk/pdbsum/5yms PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yms ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/Q9Q2P6_9REOV Q9Q2P6_9REOV]] Outer capsid protein VP5*: forms the spike "foot" and "body". Acts as a membrane permeabilization protein that mediates release of viral particles from endosomal compartments into the cytoplasm. In integrin-dependent strains, VP5* targets the integrin heterodimer ITGA2/ITGB1 for cell attachment.[SAAS:SAAS00136874] VP8* forms the head of the spikes. It is the viral hemagglutinin and an important target of neutralizing antibodies. In sialic acid-dependent strains, VP8* binds to host cell sialic acid, most probably a ganglioside, providing the initial contact.[SAAS:SAAS00136880] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Dandi, L]] | |||
[[Category: Duan, Z]] | |||
[[Category: Sun, X]] | |||
[[Category: Mucin core2core 2]] | |||
[[Category: Viral protein]] | |||
[[Category: Vp8*]] | |||
Revision as of 08:05, 2 May 2018
Structural basis of glycan specificity and identification of a novel glycan binding cavity in human P[19] rotavirus
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