Sandbox Reserved 1452: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
Uricase is mainly located in the liver where it forms an elctron dense crystalline core in peroxisomes. It is a tetramer of identical subunits each containing copper binding sites. X-ray crystallography shows that uric acid binds to the active site as a monoanion and is deprotonated as a dianion which is then stabilized by <scene name='77/778332/1vax_substrate_binding/1'>Arg | Uricase is mainly located in the liver where it forms an elctron dense crystalline core in peroxisomes. It is a tetramer of identical subunits each containing copper binding sites. X-ray crystallography shows that uric acid binds to the active site as a monoanion and is deprotonated as a dianion which is then stabilized by <scene name='77/778332/1vax_substrate_binding/1'>Arg 176 and Gln 228.</scene> This specific enzyme is found in Aspergillus flavus which is a type of bacteria. Uricase can be inhibited by both cyanide and chloride ions. Oxonate competitively inhibits uricase. | ||
This is <scene name='77/778332/1vax/1'>uricase</scene> without a ligand. | This is <scene name='77/778332/1vax/1'>uricase</scene> without a ligand. | ||
You can view uricase with a ligand <scene name='77/778332/4mb8/1'>here.</scene> | You can view uricase with a ligand <scene name='77/778332/4mb8/1'>here.</scene> | ||
