2huw: Difference between revisions
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|PDB= 2huw |SIZE=350|CAPTION= <scene name='initialview01'>2huw</scene>, resolution 1.900Å | |PDB= 2huw |SIZE=350|CAPTION= <scene name='initialview01'>2huw</scene>, resolution 1.900Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> | |LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=YVN:N-({(1R,2R,3S)-2-[(METHYLAMINO)CARBONYL]-3-[4-(PHOSPHONOOXY)PHENYL]CYCLOPROPYL}CARBONYL)-L-VALYL-L-ASPARTAMIDE'>YVN</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= GRB2, ASH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= GRB2, ASH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2huw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2huw OCA], [http://www.ebi.ac.uk/pdbsum/2huw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2huw RCSB]</span> | |||
}} | }} | ||
'''X-ray crystal structure of the Grb2 SH2 domain complexed to a constrained and cyclopropane-derived ligand''' | '''X-ray crystal structure of the Grb2 SH2 domain complexed to a constrained and cyclopropane-derived ligand''' | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Benfield, A P.]] | [[Category: Benfield, A P.]] | ||
[[Category: Martin, S F.]] | [[Category: Martin, S F.]] | ||
[[Category: contrained]] | [[Category: contrained]] | ||
[[Category: cylcopropane]] | [[Category: cylcopropane]] | ||
[[Category: grb2]] | [[Category: grb2]] | ||
[[Category: preorganization]] | [[Category: preorganization,]] | ||
[[Category: sh2]] | [[Category: sh2]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:35:49 2008'' | ||
Revision as of 00:35, 31 March 2008
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| 2huw, resolution 1.900Å | |||||||||||||
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| Ligands: | PO4, YVN | ||||||||||||
| Gene: | GRB2, ASH (Homo sapiens) | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
X-ray crystal structure of the Grb2 SH2 domain complexed to a constrained and cyclopropane-derived ligand
About this Structure
2HUW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Ligand preorganization may be accompanied by entropic penalties in protein-ligand interactions., Benfield AP, Teresk MG, Plake HR, DeLorbe JE, Millspaugh LE, Martin SF, Angew Chem Int Ed Engl. 2006 Oct 20;45(41):6830-5. PMID:17001728
Page seeded by OCA on Mon Mar 31 03:35:49 2008
