5o6h: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5o6h is ~~ON HOLD~~

==Human NMT1 in complex with myristoyl-CoA and inhibitor IMP-917==

~~Authors~~: ~~Brannigan~~, J.A., ~~Wilkinson~~, A.J.

== Structural highlights ==

<table><tr><td colspan='2'>[[5o6h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O6H OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O6H FirstGlance].

~~Description~~: ~~Human NMT1 in complex with~~ myristoyl-~~CoA~~ and ~~inhibitor IMP~~-~~917~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=9M2:1-[5-[4-fluoranyl-2-[2-(1,3,5-trimethylpyrazol-4-yl)ethoxy]phenyl]-2~{H}-indazol-3-yl]-~{N},~{N}-dimethyl-methanamine'>9M2</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5mu6|5mu6]], [[5o6j|5o6j]]</td></tr>

[[Category: Wilkinson, A.J]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </td></tr>

[[Category: ~~Brannigan, J.A~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o6h OCA], [http://pdbe.org/5o6h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o6h RCSB], [http://www.ebi.ac.uk/pdbsum/5o6h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o6h ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/NMT1_HUMAN NMT1_HUMAN]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

__TOC__

</StructureSection>

[[Category: Glycylpeptide N-tetradecanoyltransferase]]

[[Category: Brannigan, J A]]

[[Category: Wilkinson, A J]]

[[Category: Inhibitor]]

[[Category: Myristoyl]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5o6h is ON HOLD
+==Human NMT1 in complex with myristoyl-CoA and inhibitor IMP-917==
+<StructureSection load='5o6h' size='340' side='right' caption='[[5o6h]], [[Resolution|resolution]] 1.29&Aring;' scene=''>
-Authors: Brannigan, J.A., Wilkinson, A.J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5o6h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O6H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O6H FirstGlance]. <br>
-Description: Human NMT1 in complex with myristoyl-CoA and inhibitor IMP-917
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9M2:1-[5-[4-fluoranyl-2-[2-(1,3,5-trimethylpyrazol-4-yl)ethoxy]phenyl]-2~{H}-indazol-3-yl]-~{N},~{N}-dimethyl-methanamine'>9M2</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5mu6|5mu6]], [[5o6j|5o6j]]</td></tr>
-[[Category: Wilkinson, A.J]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
-[[Category: Brannigan, J.A]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o6h OCA], [http://pdbe.org/5o6h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o6h RCSB], [http://www.ebi.ac.uk/pdbsum/5o6h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o6h ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/NMT1_HUMAN NMT1_HUMAN]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.
+__TOC__
+</StructureSection>
+[[Category: Glycylpeptide N-tetradecanoyltransferase]]
+[[Category: Brannigan, J A]]
+[[Category: Wilkinson, A J]]
+[[Category: Inhibitor]]
+[[Category: Myristoyl]]
+[[Category: Transferase]]