6bo2: Difference between revisions
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==Adducts formed after 1 month in the reaction of dichlorido(1,3-dimethylbenzimidazol-2-ylidene)(eta6-p-cymene)ruthenium(II) with HEWL== | |||
<StructureSection load='6bo2' size='340' side='right' caption='[[6bo2]], [[Resolution|resolution]] 1.48Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6bo2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BO2 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=E3D:dichloro(1,3-dimethyl-1H-benzimidazol-3-ium-2-yl)ruthenium'>E3D</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RU:RUTHENIUM+ION'>RU</scene></td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bo2 OCA], [http://pdbe.org/6bo2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bo2 RCSB], [http://www.ebi.ac.uk/pdbsum/6bo2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bo2 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The first X-ray structures of adducts formed between a RuII(N-heterocyclic carbene)(eta6-p-cymene) compound and a protein are reported. Coordination to the protein induced the cleavage of the cymene ligand and EPR spectroscopy demonstrated the oxidation of the Ru centre. | |||
Unexpected arene ligand exchange results in the oxidation of an organoruthenium anticancer agent: the first X-ray structure of a protein-Ru(carbene) adduct.,Sullivan MP, Nieuwoudt MK, Bowmaker GA, Lam NYS, Truong D, Goldstone DC, Hartinger CG Chem Commun (Camb). 2018 May 1. doi: 10.1039/c8cc02433b. PMID:29713703<ref>PMID:29713703</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 6bo2" style="background-color:#fffaf0;"></div> | ||
[[Category: Goldstone, D | == References == | ||
[[Category: Hartinger, C | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Gallus gallus]] | |||
[[Category: Lysozyme]] | |||
[[Category: Goldstone, D C]] | |||
[[Category: Hartinger, C G]] | |||
[[Category: Sullivan, M P]] | |||
[[Category: Anticancer]] | |||
[[Category: Benzimidazole]] | |||
[[Category: Carbene]] | |||
[[Category: Dimethylbenzimidazole]] | |||
[[Category: Hydrolase]] | |||
[[Category: Metal-based]] | |||
[[Category: Metallodrug]] | |||
[[Category: Nhc]] | |||
[[Category: Ruthenium]] | |||
