6c0b: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6c0b is ~~ON HOLD until Paper Publication~~

==Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6c0b]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C0B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C0B FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c0b OCA], [http://pdbe.org/6c0b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c0b RCSB], [http://www.ebi.ac.uk/pdbsum/6c0b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c0b ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/FZD2_HUMAN FZD2_HUMAN]] Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

__TOC__

</StructureSection>

[[Category: Chen, P]]

[[Category: Jin, R]]

[[Category: Lam, K]]

[[Category: Complex]]

[[Category: Toxin]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6c0b is ON HOLD  until Paper Publication
+==Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B==
+<StructureSection load='6c0b' size='340' side='right' caption='[[6c0b]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6c0b]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C0B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C0B FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PAM:PALMITOLEIC+ACID'>PAM</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c0b OCA], [http://pdbe.org/6c0b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c0b RCSB], [http://www.ebi.ac.uk/pdbsum/6c0b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c0b ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/FZD2_HUMAN FZD2_HUMAN]] Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
+__TOC__
+</StructureSection>
+[[Category: Chen, P]]
+[[Category: Jin, R]]
+[[Category: Lam, K]]
+[[Category: Complex]]
+[[Category: Toxin]]