Practical Guide to Homology Modeling: Difference between revisions
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== Do you need a homology model? == | == Do you need a homology model? == | ||
You don’t need a homology model if the amino acid sequence of interest (the query sequence) already has an empirically determined 3D structure. Structures determined empirically, by X-ray crystallography or (much less often) by solution NMR, will almost always be more accurate than a homology model. | You don’t need a homology model if the amino acid sequence of interest (the query sequence) already has an empirically determined 3D structure. Structures determined empirically, by X-ray crystallography or (much less often) by solution NMR or cryo-EM, will almost always be more accurate than a homology model. | ||
=== Is there an empirical model? === | === Is there an empirical model? === | ||
