5xmx: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Co-crystal structure of Inhibitor compound in complex with human PPARdelta LBD== | |||
<StructureSection load='5xmx' size='340' side='right' caption='[[5xmx]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5xmx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XMX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XMX FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=89L:(E)-6-[2-[[[4-(furan-2-yl)phenyl]carbonyl-methyl-amino]methyl]phenoxy]-4-methyl-hex-4-enoic+acid'>89L</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xmx OCA], [http://pdbe.org/5xmx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xmx RCSB], [http://www.ebi.ac.uk/pdbsum/5xmx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xmx ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN]] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Optimization of benzamide PPARdelta modulator 1 led to (E)-6-(2-((4-(furan-2-yl)-N-methylbenzamido)methyl)phenoxy)-4-methylhex-4-enoic acid (18), a potent selective PPARdelta modulator with significantly improved exposure in multiple species following oral administration. | |||
Novel highly selective peroxisome proliferator-activated receptor delta (PPARdelta) modulators with pharmacokinetic properties suitable for once-daily oral dosing.,Lagu B, Kluge AF, Fredenburg RA, Tozzo E, Senaiar RS, Jaleel M, Panigrahi SK, Tiwari NK, Krishnamurthy NR, Takahashi T, Patane MA Bioorg Med Chem Lett. 2017 Dec 1;27(23):5230-5234. doi:, 10.1016/j.bmcl.2017.10.037. Epub 2017 Oct 27. PMID:29103972<ref>PMID:29103972</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 5xmx" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Krishnamurthy, N]] | [[Category: Krishnamurthy, N]] | ||
[[Category: Lakshminarasimhan, A]] | [[Category: Lakshminarasimhan, A]] | ||
[[Category: Rani, S T]] | |||
[[Category: Senaiar, R S]] | |||
[[Category: Inhibitor compound]] | |||
[[Category: Ppardelta]] | |||
[[Category: Transcription-inhibitor complex]] | |||
Revision as of 07:16, 23 May 2018
Co-crystal structure of Inhibitor compound in complex with human PPARdelta LBD
| ||||||||||||
