5nyi: Difference between revisions
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==Crystal Structure of Hsp90-alpha N-Domain in complex with Resorcinol derivative== | |||
<StructureSection load='5nyi' size='340' side='right' caption='[[5nyi]], [[Resolution|resolution]] 1.44Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5nyi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NYI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NYI FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2EQ:5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-[4-(MORPHOLIN-4-YLMETHYL)PHENYL]ISOXAZOLE-3-CARBOXAMIDE'>2EQ</scene></td></tr> | |||
[[ | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5nyh|5nyh]], [[5nyd|5nyd]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nyi OCA], [http://pdbe.org/5nyi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nyi RCSB], [http://www.ebi.ac.uk/pdbsum/5nyi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nyi ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Amaral, M]] | [[Category: Amaral, M]] | ||
[[Category: Chaperone]] | |||
Revision as of 05:26, 30 May 2018
Crystal Structure of Hsp90-alpha N-Domain in complex with Resorcinol derivative
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