6fxa: Difference between revisions
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The | ==Dimerization domain of TP901-1 CI repressor== | ||
<StructureSection load='6fxa' size='340' side='right' caption='[[6fxa]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6fxa]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FXA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FXA FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a7l|5a7l]], [[3zhi|3zhi]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fxa OCA], [http://pdbe.org/6fxa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fxa RCSB], [http://www.ebi.ac.uk/pdbsum/6fxa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fxa ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Temperate bacteriophages are known for their bistability, which in TP901-1 is controlled by two proteins, CI and MOR. Clear 1 repressor (CI) is hexameric and binds three palindromic operator sites via an N-terminal helix-turn-helix domain (NTD). A dimeric form, such as the truncated CI58 investigated here, is necessary for high-affinity binding to DNA. The crystal structure of the dimerization region (CTD1 ) is determined here, showing that it forms a pair of helical hooks. This newly determined structure is used together with the known crystal structure of the CI-NTD and small angle X-ray scattering data, to determine the solution structure of CI58 in complex with a palindromic operator site, showing that the two NTDs bind on opposing sides of the DNA helix. | |||
Structural basis of the bacteriophage TP901-1 CI repressor dimerization and interaction with DNA.,Rasmussen KK, Varming AK, Schmidt SN, Frandsen KEH, Thulstrup PW, Jensen MR, Lo Leggio L FEBS Lett. 2018 Apr 23. doi: 10.1002/1873-3468.13060. PMID:29683476<ref>PMID:29683476</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6fxa" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Leggio, L Lo]] | |||
[[Category: Rasmussen, K K]] | |||
[[Category: Varming, A K]] | |||
[[Category: Ci repressor]] | |||
[[Category: Dimerization domain]] | |||
[[Category: Helical hook]] | |||
[[Category: Transcription]] | |||
[[Category: Viral protein]] | |||
Revision as of 05:39, 30 May 2018
Dimerization domain of TP901-1 CI repressor
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