User:Luis Netto/Sandbox 1: Difference between revisions
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==Ohr == | ==Ohr == | ||
<StructureSection load='1ZB8' size='340' side='right' caption='Caption | <StructureSection load='1ZB8' size='340' side='right' caption='Caption overall Ohr structure' scene=''> | ||
Ohr (Organic Hydroperoxide Resistance Protein)[[1zb8]] is a Cys based peroxidase <ref>PMID: 12540833</ref>,<ref>PMID: 12485986</ref> | Ohr (Organic Hydroperoxide Resistance Protein)[[1zb8]] is a Cys based peroxidase <ref>PMID: 12540833</ref>,<ref>PMID: 12485986</ref> | ||
that display higher preference for hydrogen peroxide (H2O2) than for organic hydroperoxides. Accordingly, bacteria with the gene for Ohr deleted displayed increased sensitivity for organic hydroperoxides but not for hydrogen peroxide <ref>PMID: 9573147</ref>. | that display higher preference for hydrogen peroxide (H2O2) than for organic hydroperoxides. Accordingly, bacteria with the gene for Ohr deleted displayed increased sensitivity for organic hydroperoxides but not for hydrogen peroxide <ref>PMID: 9573147</ref>. | ||
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== Structural highlights == | == Structural highlights == | ||
Ohr is a homo-dimer, with a symmetrical,oval shape. The two monomers are tightly wrapped around each other in a head-to-tail orientation to generate a compact quaternary structure.[[Image:Homodimer_Ohr.png]] | |||
Arg19 and Glu 50 of one chain (lets say chain A) compose the <scene name='78/785321/Catalytic_triad/1'>catalytic triad</scene> triad with Cys61 of the other chain (in this case chain B). | Arg19 and Glu 50 of one chain (lets say chain A) compose the <scene name='78/785321/Catalytic_triad/1'>catalytic triad</scene> triad with Cys61 of the other chain (in this case chain B). | ||
Ohr is a tight homo-dimer a | |||
== References == | == References == | ||
<references/> | <references/> | ||
