5mgt: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5mgt is ~~ON HOLD~~ ~~until Paper Publication~~

==Complex of human NKR-P1 and LLT1 in deglycosylated forms==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5mgt]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MGT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MGT FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mgt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mgt OCA], [http://pdbe.org/5mgt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mgt RCSB], [http://www.ebi.ac.uk/pdbsum/5mgt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mgt ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/CLC2D_HUMAN CLC2D_HUMAN]] Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon-gamma. Binds high molecular weight sulfated glycosaminoglycans.<ref>PMID:14753741</ref> <ref>PMID:15104121</ref> <ref>PMID:16339513</ref> [[http://www.uniprot.org/uniprot/KLRB1_HUMAN KLRB1_HUMAN]] Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.<ref>PMID:16455998</ref> <ref>PMID:16925668</ref> <ref>PMID:8077657</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Blaha, J]]

[[Category: Dohnalek, J]]

[[Category: Harlos, K]]

[[Category: Hasek, J]]

[[Category: Koval, T]]

[[Category: Skalova, T]]

[[Category: Stransky, J]]

[[Category: Vanek, O]]

[[Category: Yuguang, Z]]

[[Category: Ctl fold]]

[[Category: Immune system]]

[[Category: Natural killer cell]]

[[Category: Receptor]]

[[Category: Receptor-ligand complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5mgt is ON HOLD  until Paper Publication
+==Complex of human NKR-P1 and LLT1 in deglycosylated forms==
+<StructureSection load='5mgt' size='340' side='right' caption='[[5mgt]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5mgt]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MGT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MGT FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mgt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mgt OCA], [http://pdbe.org/5mgt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mgt RCSB], [http://www.ebi.ac.uk/pdbsum/5mgt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mgt ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CLC2D_HUMAN CLC2D_HUMAN]] Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon-gamma. Binds high molecular weight sulfated glycosaminoglycans.<ref>PMID:14753741</ref> <ref>PMID:15104121</ref> <ref>PMID:16339513</ref>  [[http://www.uniprot.org/uniprot/KLRB1_HUMAN KLRB1_HUMAN]] Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.<ref>PMID:16455998</ref> <ref>PMID:16925668</ref> <ref>PMID:8077657</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Blaha, J]]
+[[Category: Dohnalek, J]]
+[[Category: Harlos, K]]
+[[Category: Hasek, J]]
+[[Category: Koval, T]]
+[[Category: Skalova, T]]
+[[Category: Stransky, J]]
+[[Category: Vanek, O]]
+[[Category: Yuguang, Z]]
+[[Category: Ctl fold]]
+[[Category: Immune system]]
+[[Category: Natural killer cell]]
+[[Category: Receptor]]
+[[Category: Receptor-ligand complex]]