5u85: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5u85 is ~~ON HOLD~~ ~~until Paper Publication~~

==Murine saposin-D (SapD), open conformation==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[5u85]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U85 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U85 FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u85 OCA], [http://pdbe.org/5u85 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u85 RCSB], [http://www.ebi.ac.uk/pdbsum/5u85 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u85 ProSAT]</span></td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/SAP_MOUSE SAP_MOUSE]] Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.<ref>PMID:23690594</ref> Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.[UniProtKB:P07602] Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.[UniProtKB:P07602] Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12).[UniProtKB:P07602] Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.[UniProtKB:P07602]

== References ==

__TOC__

</StructureSection>

[[Category: Gebai, A]]

[[Category: Gorelik, A]]

[[Category: Illes, K]]

[[Category: Nagar, B]]

[[Category: Hydrolase]]

[[Category: Saposin]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5u85 is ON HOLD  until Paper Publication
+==Murine saposin-D (SapD), open conformation==
+<StructureSection load='5u85' size='340' side='right' caption='[[5u85]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5u85]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U85 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U85 FirstGlance]. <br>
-Description:
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u85 OCA], [http://pdbe.org/5u85 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u85 RCSB], [http://www.ebi.ac.uk/pdbsum/5u85 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u85 ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/SAP_MOUSE SAP_MOUSE]] Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.<ref>PMID:23690594</ref>   Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.[UniProtKB:P07602]  Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.[UniProtKB:P07602]  Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12).[UniProtKB:P07602]  Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.[UniProtKB:P07602]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Gebai, A]]
+[[Category: Gorelik, A]]
+[[Category: Illes, K]]
+[[Category: Nagar, B]]
+[[Category: Hydrolase]]
+[[Category: Saposin]]