2j9a: Difference between revisions
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|PDB= 2j9a |SIZE=350|CAPTION= <scene name='initialview01'>2j9a</scene>, resolution 1.73Å | |PDB= 2j9a |SIZE=350|CAPTION= <scene name='initialview01'>2j9a</scene>, resolution 1.73Å | ||
|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene> | |SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene> | ||
|LIGAND= <scene name='pdbligand= | |LIGAND= <scene name='pdbligand=AHY:(2S,3R)-3-AMINO-2-HYDROXYDECANOIC+ACID'>AHY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j9a OCA], [http://www.ebi.ac.uk/pdbsum/2j9a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2j9a RCSB]</span> | |||
}} | }} | ||
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[[Category: Schulz, G E.]] | [[Category: Schulz, G E.]] | ||
[[Category: Weckesser, J.]] | [[Category: Weckesser, J.]] | ||
[[Category: acetylation]] | [[Category: acetylation]] | ||
[[Category: aminopeptidase]] | [[Category: aminopeptidase]] | ||
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[[Category: protease]] | [[Category: protease]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:54:54 2008'' | ||
Revision as of 00:55, 31 March 2008
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| 2j9a, resolution 1.73Å | |||||||||||||
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| Sites: | AC1 | ||||||||||||
| Ligands: | AHY, CL, DMS, MLE, MPD, ZN | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
BLLAP IN COMPLEX WITH MICROGININ FR1
Overview
Natural bioactive compounds are of general interest for pharmaceutical research because they may serve as leads in drug development campaigns. Among them, microginins are linear peptides known to inhibit various exopeptidases. The crystal structure of microginin FR1 from Microcystis sp. bound to bovine lens leucine aminopeptidase was established at 1.73 Angstrom resolution. The observed binding structure could be beneficial for the design of potent aminopeptidase inhibitors.
About this Structure
2J9A is a Single protein structure of sequence from Bos taurus and Microcystis sp.. Full crystallographic information is available from OCA.
Reference
Binding structure of the leucine aminopeptidase inhibitor microginin FR1., Kraft M, Schleberger C, Weckesser J, Schulz GE, FEBS Lett. 2006 Dec 22;580(30):6943-7. Epub 2006 Dec 4. PMID:17157838
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