User:Ricardo Alberto Chiong Zevallos/Sandbox 1: Difference between revisions
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== Function == | == Function == | ||
B-cell-specific Moloney leukemia virus insertion site 1 (BMI1) is a ring finger protein that is component of a <scene name='78/787701/2h0d/2'>Polycomb group (PcG) multiprotein PRC1 complex</scene>, which epigenetically repress regulatory genes, such as Hox genes, related to embryonic development and self-renewal of somatic stem-cells. The name come from the original identification of BMI1 as an oncogene cooperating with a myc | B-cell-specific Moloney leukemia virus insertion site 1 (BMI1) is a ring finger protein that is component of a <scene name='78/787701/2h0d/2'>Polycomb group (PcG) multiprotein PRC1 complex</scene>, which epigenetically repress regulatory genes, such as Hox genes, related to embryonic development and self-renewal of somatic stem-cells. The name come from the original identification of BMI1 as an oncogene cooperating with a myc gene in lymphomagenesis <ref>DOI: 10.1038/16476</ref> . It became clear that the Bmi1 protein is part of an E3 ubiquitin ligase complex (PRC1) <ref>DOI: 10.1038/nature02985</ref> and that this complex has an important role in gene regulation during development. | ||
Monoubiquitinated H2A is enriched on the inactive human female X-chromosome. The inactivation of one of the X-chromosome is responsible for “dosing” the X-chromosome expression, which leads to the physiological X expression levels in females similar to the X expression levels in males (which has only one X). | Monoubiquitinated H2A is enriched on the inactive human female X-chromosome. The inactivation of one of the X-chromosome is responsible for “dosing” the X-chromosome expression, which leads to the physiological X expression levels in females similar to the X expression levels in males (which has only one X). | ||
