6bwr: Difference between revisions
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==LarC2, the C-terminal domain of a cyclometallase involved in the synthesis of the NPN cofactor of lactate racemase, in complex with nickel== | |||
<StructureSection load='6bwr' size='340' side='right' caption='[[6bwr]], [[Resolution|resolution]] 1.81Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6bwr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BWR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BWR FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bwr OCA], [http://pdbe.org/6bwr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bwr RCSB], [http://www.ebi.ac.uk/pdbsum/6bwr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bwr ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/LARC_LACPL LARC_LACPL]] Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is required for the activation of the lactate racemase LarA. May also be involved in the activation of other nickel-pincer cofactor-dependent enzymes.<ref>PMID:24710389</ref> <ref>PMID:27114550</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Fellner, M]] | |||
[[Category: Hausinger, R P]] | |||
[[Category: Hu, J]] | |||
[[Category: Ctp]] | |||
[[Category: Hexamer]] | |||
[[Category: Lactate]] | |||
[[Category: Lactate racemase]] | |||
[[Category: Lactate racemization]] | |||
[[Category: Lar]] | |||
[[Category: Larc]] | |||
[[Category: Metal binding protein]] | |||
[[Category: Nickel]] | |||
[[Category: Nickel transferase]] | |||
[[Category: Trimer]] | |||
Revision as of 05:49, 20 June 2018
LarC2, the C-terminal domain of a cyclometallase involved in the synthesis of the NPN cofactor of lactate racemase, in complex with nickel
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