6d9h: Difference between revisions

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'''Unreleased structure'''


The entry 6d9h is ON HOLD  until Paper Publication
==Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist==
 
<StructureSection load='6d9h' size='340' side='right' caption='[[6d9h]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
Authors: Draper-Joyce, C.J., Khoshouei, M., Thal, D.M., Liang, Y.-L., Nguyen, A.T.N., Furness, S.G.B., Venugopal, H., Baltos, J., Plitzko, J.M., Danev, R., Baumeister, W., May, L.T., Wootten, D., Sexton, P., Glukhova, A., Christopoulos, A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6d9h]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D9H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D9H FirstGlance]. <br>
Description: Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d9h OCA], [http://pdbe.org/6d9h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d9h RCSB], [http://www.ebi.ac.uk/pdbsum/6d9h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d9h ProSAT]</span></td></tr>
[[Category: Nguyen, A.T.N]]
</table>
[[Category: May, L.T]]
== Function ==
[[Category: Plitzko, J.M]]
[[http://www.uniprot.org/uniprot/ACM4_HUMAN ACM4_HUMAN]] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase. [[http://www.uniprot.org/uniprot/GNAI2_HUMAN GNAI2_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.<ref>PMID:17635935</ref>  Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool.<ref>PMID:17550964</ref>  [[http://www.uniprot.org/uniprot/GBG2_HUMAN GBG2_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). [[http://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref> 
[[Category: Venugopal, H]]
== References ==
[[Category: Sexton, P]]
<references/>
[[Category: Furness, S.G.B]]
__TOC__
</StructureSection>
[[Category: Baltos, J]]
[[Category: Baumeister, W]]
[[Category: Baumeister, W]]
[[Category: Wootten, D]]
[[Category: Thal, D.M]]
[[Category: Christopoulos, A]]
[[Category: Christopoulos, A]]
[[Category: Danev, R]]
[[Category: Draper-Joyce, C J]]
[[Category: Furness, S G.B]]
[[Category: Glukhova, A]]
[[Category: Glukhova, A]]
[[Category: Draper-Joyce, C.J]]
[[Category: Khoshouei, M]]
[[Category: Khoshouei, M]]
[[Category: Danev, R]]
[[Category: Liang, Y L]]
[[Category: Baltos, J]]
[[Category: May, L T]]
[[Category: Liang, Y.-L]]
[[Category: Nguyen, A T.N]]
[[Category: Plitzko, J M]]
[[Category: Sexton, P]]
[[Category: Thal, D M]]
[[Category: Venugopal, H]]
[[Category: Wootten, D]]
[[Category: Active-state g protein-coupled receptor]]
[[Category: Adenosine a1 receptor]]
[[Category: Membrane protein]]
[[Category: Signaling protein]]
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