5o97: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5o97 is ~~ON HOLD~~

==Crystal structure of human BRD4(1) bromodomain in complex with JRMBR4106==

~~Authors~~: ~~Zhu~~, J., ~~Marchand~~, J.R., ~~Caflisch~~, A.

== Structural highlights ==

<table><tr><td colspan='2'>[[5o97]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O97 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O97 FirstGlance]. <br>

~~Description~~: ~~Crystal structure~~ of ~~human BRD4~~(1) ~~bromodomain in complex~~ with ~~JRMBR4106~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9OE:(5~{Z})-4-azanyl-5-[(3-methoxy-4-oxidanyl-phenyl)methylidene]-1,3-thiazol-2-one'>9OE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o97 OCA], [http://pdbe.org/5o97 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o97 RCSB], [http://www.ebi.ac.uk/pdbsum/5o97 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o97 ProSAT]</span></td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>

== Function ==

[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

== References ==

__TOC__

</StructureSection>

[[Category: Caflisch, A]]

[[Category: Marchand, J.R]]

[[Category: Marchand, J R]]

[[Category: Zhu, J]]

[[Category: Dna binding protein]]

[[Category: Inhibitor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5o97 is ON HOLD
+==Crystal structure of human BRD4(1) bromodomain in complex with JRMBR4106==
+<StructureSection load='5o97' size='340' side='right' caption='[[5o97]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
-Authors: Zhu, J., Marchand, J.R., Caflisch, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5o97]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O97 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O97 FirstGlance]. <br>
-Description: Crystal structure of human BRD4(1) bromodomain in complex with JRMBR4106
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9OE:(5~{Z})-4-azanyl-5-[(3-methoxy-4-oxidanyl-phenyl)methylidene]-1,3-thiazol-2-one'>9OE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o97 OCA], [http://pdbe.org/5o97 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o97 RCSB], [http://www.ebi.ac.uk/pdbsum/5o97 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o97 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Caflisch, A]]
-[[Category: Marchand, J.R]]
+[[Category: Marchand, J R]]
 [[Category: Zhu, J]]
+[[Category: Dna binding protein]]
+[[Category: Inhibitor]]