6d12: Difference between revisions
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==Crystal structure of C-terminal xRRM domain of human Larp7 bound to 7SK stem-loop 4 RNA== | |||
<StructureSection load='6d12' size='340' side='right' caption='[[6d12]], [[Resolution|resolution]] 2.21Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6d12]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D12 FirstGlance]. <br> | |||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d12 OCA], [http://pdbe.org/6d12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d12 RCSB], [http://www.ebi.ac.uk/pdbsum/6d12 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d12 ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/LARP7_HUMAN LARP7_HUMAN]] Microcephalic primordial dwarfism, Alazami type. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/LARP7_HUMAN LARP7_HUMAN]] Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.<ref>PMID:18249148</ref> <ref>PMID:18483487</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Cascio, D]] | |||
[[Category: Eichhorn, C D]] | |||
[[Category: Feigon, J]] | [[Category: Feigon, J]] | ||
[[Category: | [[Category: Sawaya, M R]] | ||
[[Category: | [[Category: Rna apical loop]] | ||
[[Category: | [[Category: Rna binding protein-rna complex]] | ||
[[Category: Rna recognition motif]] | |||
[[Category: Rrm]] | |||
Revision as of 05:37, 27 June 2018
Crystal structure of C-terminal xRRM domain of human Larp7 bound to 7SK stem-loop 4 RNA
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