6fc1: Difference between revisions
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==Crystal structure of the eIF4E-Eap1p complex from Saccharomyces cerevisiae in the cap-bound state== | |||
<StructureSection load='6fc1' size='340' side='right' caption='[[6fc1]], [[Resolution|resolution]] 1.35Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6fc1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FC1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FC1 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MGP:7-METHYL-GUANOSINE-5-TRIPHOSPHATE'>MGP</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fc1 OCA], [http://pdbe.org/6fc1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fc1 RCSB], [http://www.ebi.ac.uk/pdbsum/6fc1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fc1 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/IF4E_YEAST IF4E_YEAST]] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. [[http://www.uniprot.org/uniprot/EAP1_YEAST EAP1_YEAST]] Can regulate translation through binding to eIF4E. Competes with eIF4G and p20 for binding to eIF4E in vivo and inhibits cap-dependent translation in vitro. Plays a role in cell growth and is implicated in the TOR signaling cascade. Functions independently of eIF4E to maintain genetic stability and to attenuate GCN4 translation upon TOR inactivation.<ref>PMID:10848587</ref> <ref>PMID:11114520</ref> <ref>PMID:15848184</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Gruener, S]] | |||
[[Category: Valkov, E]] | |||
[[Category: Gene expression translation translation initiation translational control]] | |||
[[Category: Translation]] | |||
Revision as of 05:40, 27 June 2018
Crystal structure of the eIF4E-Eap1p complex from Saccharomyces cerevisiae in the cap-bound state
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