6fc2: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6fc2 is ~~ON HOLD~~ ~~until Paper Publication~~

==Crystal structure of the eIF4E-Eap1p complex from Saccharomyces cerevisiae==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6fc2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FC2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FC2 FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fc2 OCA], [http://pdbe.org/6fc2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fc2 RCSB], [http://www.ebi.ac.uk/pdbsum/6fc2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fc2 ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/IF4E_YEAST IF4E_YEAST]] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. [[http://www.uniprot.org/uniprot/EAP1_YEAST EAP1_YEAST]] Can regulate translation through binding to eIF4E. Competes with eIF4G and p20 for binding to eIF4E in vivo and inhibits cap-dependent translation in vitro. Plays a role in cell growth and is implicated in the TOR signaling cascade. Functions independently of eIF4E to maintain genetic stability and to attenuate GCN4 translation upon TOR inactivation.<ref>PMID:10848587</ref> <ref>PMID:11114520</ref> <ref>PMID:15848184</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Gruener, S]]

[[Category: Valkov, E]]

[[Category: Gene expression translation translational control 4e-binding protein]]

[[Category: Translation]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6fc2 is ON HOLD  until Paper Publication
+==Crystal structure of the eIF4E-Eap1p complex from Saccharomyces cerevisiae==
+<StructureSection load='6fc2' size='340' side='right' caption='[[6fc2]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6fc2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FC2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FC2 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fc2 OCA], [http://pdbe.org/6fc2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fc2 RCSB], [http://www.ebi.ac.uk/pdbsum/6fc2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fc2 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/IF4E_YEAST IF4E_YEAST]] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. [[http://www.uniprot.org/uniprot/EAP1_YEAST EAP1_YEAST]] Can regulate translation through binding to eIF4E. Competes with eIF4G and p20 for binding to eIF4E in vivo and inhibits cap-dependent translation in vitro. Plays a role in cell growth and is implicated in the TOR signaling cascade. Functions independently of eIF4E to maintain genetic stability and to attenuate GCN4 translation upon TOR inactivation.<ref>PMID:10848587</ref> <ref>PMID:11114520</ref> <ref>PMID:15848184</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Gruener, S]]
+[[Category: Valkov, E]]
+[[Category: Gene expression translation translational control 4e-binding protein]]
+[[Category: Translation]]