5ysm: Difference between revisions
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==Crystal Structure Analysis of Rif16== | |||
<StructureSection load='5ysm' size='340' side='right' caption='[[5ysm]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5ysm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YSM FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ysm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ysm OCA], [http://pdbe.org/5ysm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ysm RCSB], [http://www.ebi.ac.uk/pdbsum/5ysm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ysm ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Rifamycin-derived drugs, including rifampin, rifabutin, rifapentine, and rifaximin, have long been used as first-line therapies for the treatment of tuberculosis and other deadly infections. However, the late steps leading to the biosynthesis of the industrially important rifamycin SV and B remain largely unknown. Here, we characterize a network of reactions underlying the biosynthesis of rifamycin SV, S, L, O, and B. The two-subunit transketolase Rif15 and the cytochrome P450 enzyme Rif16 are found to mediate, respectively, a unique C-O bond formation in rifamycin L and an atypical P450 ester-to-ether transformation from rifamycin L to B. Both reactions showcase interesting chemistries for these two widespread and well-studied enzyme families. | |||
Deciphering the late steps of rifamycin biosynthesis.,Qi F, Lei C, Li F, Zhang X, Wang J, Zhang W, Fan Z, Li W, Tang GL, Xiao Y, Zhao G, Li S Nat Commun. 2018 Jun 14;9(1):2342. doi: 10.1038/s41467-018-04772-x. PMID:29904078<ref>PMID:29904078</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 5ysm" style="background-color:#fffaf0;"></div> | ||
[[Category: | == References == | ||
[[Category: Xiao, Y | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Li, F W]] | |||
[[Category: Li, S Y]] | |||
[[Category: Qi, F F]] | |||
[[Category: Xiao, Y L]] | |||
[[Category: Zhao, G P]] | |||
[[Category: Cytochrome p450]] | |||
[[Category: Metal binding protein]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: Rifamycin]] | |||
Revision as of 07:09, 4 July 2018
Crystal Structure Analysis of Rif16
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