6g2n: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 6g2n is ON HOLD until Paper Publication~~

==Crystal structure of human cytosolic 5'(3')-deoxyribonucleotidase in complex with the inhibitor PB-PAU==

~~Authors: Pachl, P., Rezacova, P., Brynda, J.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[6g2n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G2N OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G2N FirstGlance].

~~Description:~~ Crystal structure of human cytosolic 5'(3')-deoxyribonucleotidase in complex with the inhibitor PB-PAU

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=O84:[(2~{R},4~{a}~{R},6~{R},7~{a}~{R})-6-[2,4-bis(oxidanylidene)-5-[(~{E})-3-phosphonoprop-1-enyl]pyrimidin-1-yl]-2-phenyl-4~{a},6,7,7~{a}-tetrahydro-4~{H}-furo[3,2-d][1,3]dioxin-2-yl]phosphonic+acid'>O84</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>

[[~~Category~~: ~~Rezacova~~, P]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[6g22|6g22]], [[6g2l|6g2l]], [[6g2m|6g2m]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g2n OCA], [http://pdbe.org/6g2n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g2n RCSB], [http://www.ebi.ac.uk/pdbsum/6g2n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g2n ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/NT5C_HUMAN NT5C_HUMAN]] Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.

__TOC__

</StructureSection>

[[Category: Brynda, J]]

[[Category: Pachl, P]]

[[Category: Rezacova, P]]

[[Category: 5'-nucleotidase]]

[[Category: Dephosphorylation]]

[[Category: Had-like]]

[[Category: Hydrolase]]

[[Category: Hydrolase-hydrolase inhibitor complex]]

[[Category: Mitochondria]]

[[Category: Phosphorylation]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6g2n is ON HOLD  until Paper Publication
+==Crystal structure of human cytosolic 5'(3')-deoxyribonucleotidase in complex with the inhibitor PB-PAU==
+<StructureSection load='6g2n' size='340' side='right' caption='[[6g2n]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
-Authors: Pachl, P., Rezacova, P., Brynda, J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6g2n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G2N FirstGlance]. <br>
-Description: Crystal structure of human cytosolic 5'(3')-deoxyribonucleotidase in complex with the inhibitor PB-PAU
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=O84:[(2~{R},4~{a}~{R},6~{R},7~{a}~{R})-6-[2,4-bis(oxidanylidene)-5-[(~{E})-3-phosphonoprop-1-enyl]pyrimidin-1-yl]-2-phenyl-4~{a},6,7,7~{a}-tetrahydro-4~{H}-furo[3,2-d][1,3]dioxin-2-yl]phosphonic+acid'>O84</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
-[[Category: Rezacova, P]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6g22|6g22]], [[6g2l|6g2l]], [[6g2m|6g2m]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g2n OCA], [http://pdbe.org/6g2n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g2n RCSB], [http://www.ebi.ac.uk/pdbsum/6g2n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g2n ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/NT5C_HUMAN NT5C_HUMAN]] Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.
+__TOC__
+</StructureSection>
 [[Category: Brynda, J]]
 [[Category: Pachl, P]]
+[[Category: Rezacova, P]]
+[[Category: 5'-nucleotidase]]
+[[Category: Dephosphorylation]]
+[[Category: Had-like]]
+[[Category: Hydrolase]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]
+[[Category: Mitochondria]]
+[[Category: Phosphorylation]]