2j25: Difference between revisions
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== | |||
==Partially deglycosylated glucoceramidase== | |||
<StructureSection load='2j25' size='340' side='right' caption='[[2j25]], [[Resolution|resolution]] 2.90Å' scene=''> | <StructureSection load='2j25' size='340' side='right' caption='[[2j25]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2j25]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J25 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J25 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2j25]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J25 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J25 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand= | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ogs|1ogs]], [[1y7v|1y7v]], [[2f61|2f61]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ogs|1ogs]], [[1y7v|1y7v]], [[2f61|2f61]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucosylceramidase Glucosylceramidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.45 3.2.1.45] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucosylceramidase Glucosylceramidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.45 3.2.1.45] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j25 OCA], [http://pdbe.org/2j25 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j25 RCSB], [http://www.ebi.ac.uk/pdbsum/2j25 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j25 OCA], [http://pdbe.org/2j25 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2j25 RCSB], [http://www.ebi.ac.uk/pdbsum/2j25 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2j25 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j2/2j25_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j2/2j25_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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==See Also== | ==See Also== | ||
*[[Acid-beta-glucosidase|Acid-beta-glucosidase]] | *[[Acid-beta-glucosidase|Acid-beta-glucosidase]] | ||
*[[Beta-glucosidase|Beta-glucosidase]] | |||
*[[Partially deglycosylated acid-beta-glucosidase|Partially deglycosylated acid-beta-glucosidase]] | *[[Partially deglycosylated acid-beta-glucosidase|Partially deglycosylated acid-beta-glucosidase]] | ||
*[[Treatment of Gaucher disease|Treatment of Gaucher disease]] | *[[Treatment of Gaucher disease|Treatment of Gaucher disease]] | ||
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[[Category: Lysosome]] | [[Category: Lysosome]] | ||
[[Category: Membrane]] | [[Category: Membrane]] | ||
[[Category: Pharmaceutical]] | |||
[[Category: Polymorphism]] | |||
[[Category: Sphingolipid]] | [[Category: Sphingolipid]] | ||
[[Category: Sphingolipid metabolism]] | [[Category: Sphingolipid metabolism]] | ||
