5wm0: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5wm0 is ~~ON HOLD until Paper Publication~~

==Crystal structure of apo wild type peptidylglycine alpha-hydroxylating monooxygenase (PHM) soaked with peptide (peptide not observed)==

~~Authors~~: ~~Maheshwari~~, S., ~~Rudzka~~, K., ~~Gabelli, S~~.B., ~~Amzel, L~~.M.

== Structural highlights ==

<table><tr><td colspan='2'>[[5wm0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WM0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WM0 FirstGlance]. <br>

~~Description~~: ~~Crystal structure of apo wild type peptidylglycine~~ alpha-~~hydroxylating~~ monooxygenase (~~PHM~~) ~~soaked with~~ peptide ~~(peptide not observed)~~

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wm0 OCA], [http://pdbe.org/5wm0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wm0 RCSB], [http://www.ebi.ac.uk/pdbsum/5wm0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wm0 ProSAT]</span></td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/AMD_RAT AMD_RAT]] Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.

__TOC__

</StructureSection>

[[Category: Amzel, L M]]

[[Category: Gabelli, S B]]

[[Category: Maheshwari, S]]

[[Category: Rudzka, K]]

[[Category: ~~Amzel, L.M~~]]

[[Category: Metal binding protein]]

[[Category: ~~Maheshwari, S~~]]

[[Category: Oxidoreductase]]

[[Category: ~~Gabelli, S.B~~]]

[[Category: Peptidylglycine 2-hydroxylase]]

[[Category: Peptidylglycine monooxygenase]]

[[Category: Phm]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5wm0 is ON HOLD  until Paper Publication
+==Crystal structure of apo wild type peptidylglycine alpha-hydroxylating monooxygenase (PHM) soaked with peptide (peptide not observed)==
+<StructureSection load='5wm0' size='340' side='right' caption='[[5wm0]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-Authors: Maheshwari, S., Rudzka, K., Gabelli, S.B., Amzel, L.M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5wm0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WM0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WM0 FirstGlance]. <br>
-Description: Crystal structure of apo wild type peptidylglycine alpha-hydroxylating monooxygenase (PHM) soaked with peptide (peptide not observed)
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wm0 OCA], [http://pdbe.org/5wm0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wm0 RCSB], [http://www.ebi.ac.uk/pdbsum/5wm0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wm0 ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/AMD_RAT AMD_RAT]] Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.
+__TOC__
+</StructureSection>
+[[Category: Amzel, L M]]
+[[Category: Gabelli, S B]]
+[[Category: Maheshwari, S]]
 [[Category: Rudzka, K]]
-[[Category: Amzel, L.M]]
+[[Category: Metal binding protein]]
-[[Category: Maheshwari, S]]
+[[Category: Oxidoreductase]]
-[[Category: Gabelli, S.B]]
+[[Category: Peptidylglycine 2-hydroxylase]]
+[[Category: Peptidylglycine monooxygenase]]
+[[Category: Phm]]