6a4i: Difference between revisions
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==Crystal Structure of human TDO inhibitor complex== | |||
<StructureSection load='6a4i' size='340' side='right' caption='[[6a4i]], [[Resolution|resolution]] 2.65Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6a4i]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A4I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A4I FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9R9:1-(6-chloro-1H-indazol-4-yl)cyclohexan-1-ol'>9R9</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_2,3-dioxygenase Tryptophan 2,3-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.11 1.13.11.11] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a4i OCA], [http://pdbe.org/6a4i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a4i RCSB], [http://www.ebi.ac.uk/pdbsum/6a4i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a4i ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/T23O_HUMAN T23O_HUMAN]] Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Tryptophan 2,3-dioxygenase]] | |||
[[Category: Fu, G]] | [[Category: Fu, G]] | ||
[[Category: Luo, G]] | [[Category: Luo, G]] | ||
[[Category: Qian, K]] | [[Category: Qian, K]] | ||
[[Category: Wang, J]] | [[Category: Wang, J]] | ||
[[Category: Wu, G]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | |||
[[Category: Tdo holoenzyme oxygenase active site inhibitor tetramer]] | |||
Revision as of 07:33, 18 July 2018
Crystal Structure of human TDO inhibitor complex
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