6an3: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6an3 is ~~ON HOLD~~

==Crystal structure of H172A-peptidylglycine alpha-hydroxylating monooxygenase (PHM) mutant soaked with peptide (no CuH bound, no peptide bound)==

~~Authors~~: ~~Maheshwari~~, S., ~~Rudzka~~, K., ~~Gabelli, S~~.B., ~~Amzel, L~~.M.

== Structural highlights ==

<table><tr><td colspan='2'>[[6an3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AN3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AN3 FirstGlance]. <br>

~~Description~~: ~~Crystal structure of H172A~~-~~peptidylglycine~~ alpha-~~hydroxylating~~ monooxygenase (~~PHM~~) ~~mutant soaked with~~ peptide ~~(no CuH bound~~, ~~no peptide bound)~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6an3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6an3 OCA], [http://pdbe.org/6an3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6an3 RCSB], [http://www.ebi.ac.uk/pdbsum/6an3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6an3 ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/AMD_RAT AMD_RAT]] Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.

__TOC__

</StructureSection>

[[Category: Amzel, L M]]

[[Category: Gabelli, S B]]

[[Category: Maheshwari, S]]

[[Category: Rudzka, K]]

[[Category: ~~Amzel, L.M~~]]

[[Category: Oxidoreductase]]

[[Category: ~~Maheshwari, S~~]]

[[Category: Peptidylglycine 2-hydroxylase]]

[[Category: ~~Gabelli, S.B~~]]

[[Category: Peptidylglycine monooxygenase]]

[[Category: Phm]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6an3 is ON HOLD
+==Crystal structure of H172A-peptidylglycine alpha-hydroxylating monooxygenase (PHM) mutant soaked with peptide (no CuH bound, no peptide bound)==
+<StructureSection load='6an3' size='340' side='right' caption='[[6an3]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
-Authors: Maheshwari, S., Rudzka, K., Gabelli, S.B., Amzel, L.M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6an3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AN3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AN3 FirstGlance]. <br>
-Description: Crystal structure of H172A-peptidylglycine alpha-hydroxylating monooxygenase (PHM) mutant soaked with peptide (no CuH bound, no peptide bound)
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6an3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6an3 OCA], [http://pdbe.org/6an3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6an3 RCSB], [http://www.ebi.ac.uk/pdbsum/6an3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6an3 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/AMD_RAT AMD_RAT]] Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.
+__TOC__
+</StructureSection>
+[[Category: Amzel, L M]]
+[[Category: Gabelli, S B]]
+[[Category: Maheshwari, S]]
 [[Category: Rudzka, K]]
-[[Category: Amzel, L.M]]
+[[Category: Oxidoreductase]]
-[[Category: Maheshwari, S]]
+[[Category: Peptidylglycine 2-hydroxylase]]
-[[Category: Gabelli, S.B]]
+[[Category: Peptidylglycine monooxygenase]]
+[[Category: Phm]]