Ketohexokinase: Difference between revisions
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<StructureSection load='3q92' size=' | <StructureSection load='3q92' size='350' side='right' caption='Human ketohexokinase complex with ihibitor and sulfate (PDB entry [[3q92]])' scene='48/484861/Cv/1'> | ||
== Function == | == Function == | ||
'''Ketohexokinase''' (KHK) also known as hepatic fructokinase catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in the liver. The HKH gene is spliced to HKH-A and the more active HKH-C. KHK acts in the first step of fructose metabolism<ref>PMID:2996495</ref>. | '''Ketohexokinase''' (KHK) also known as hepatic fructokinase catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in the liver. The HKH gene is spliced to HKH-A and the more active HKH-C. KHK acts in the first step of fructose metabolism<ref>PMID:2996495</ref>. | ||
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[[2hw1]], [[3nbv]] – hKHK + AMPPNP + fructose<br /> | [[2hw1]], [[3nbv]] – hKHK + AMPPNP + fructose<br /> | ||
[[3nbw]] – hKHK + pyrazole derivative<br /> | [[3nbw]] – hKHK + pyrazole derivative<br /> | ||
[[3nc2]], [[3nc9]], [[3nca]], [[3ro4]], [[3q92]], [[3qa2]], [[3qai]] – hKHK + inhibitor | [[3nc2]], [[3nc9]], [[3nca]], [[3ro4]], [[3q92]], [[3qa2]], [[3qai]], [[5wbm]], [[5wbo]], [[5wbp]], [[5wbq]], [[5wbr]], [[5wbz]] – hKHK + inhibitor | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
