5wmd: Difference between revisions
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==N-terminal bromodomain of BRD4 in complex with OTX-015== | |||
<StructureSection load='5wmd' size='340' side='right' caption='[[5wmd]], [[Resolution|resolution]] 1.27Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5wmd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WMD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WMD FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6JE:2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-(4-hydroxyphenyl)acetamide'>6JE</scene></td></tr> | |||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wmd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wmd OCA], [http://pdbe.org/5wmd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wmd RCSB], [http://www.ebi.ac.uk/pdbsum/5wmd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wmd ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Zhang, Y]] | [[Category: Zhang, Y]] | ||
[[Category: Brd4]] | |||
[[Category: Bromodomain]] | |||
[[Category: Otx-015]] | |||
[[Category: Transcription]] | |||
[[Category: Transcription-transcription inhibitor complex]] | |||
Revision as of 18:37, 1 August 2018
N-terminal bromodomain of BRD4 in complex with OTX-015
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