2opy: Difference between revisions

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|PDB= 2opy |SIZE=350|CAPTION= <scene name='initialview01'>2opy</scene>, resolution 2.8&Aring;
|PDB= 2opy |SIZE=350|CAPTION= <scene name='initialview01'>2opy</scene>, resolution 2.8&Aring;
|SITE=  
|SITE=  
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=CO9:1-({2-[(1S)-1-AMINOETHYL]-1,3-OXAZOL-4-YL}CARBONYL)-L-PROLYL-L-TRYPTOPHAN'>CO9</scene>
|LIGAND= <scene name='pdbligand=CO9:1-({2-[(1S)-1-AMINOETHYL]-1,3-OXAZOL-4-YL}CARBONYL)-L-PROLYL-L-TRYPTOPHAN'>CO9</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
|ACTIVITY=  
|ACTIVITY=  
|GENE= BIRC4, API3, IAP3, XIAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|GENE= BIRC4, API3, IAP3, XIAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|DOMAIN=
|RELATEDENTRY=[[1g3f|1G3F]], [[1g73|1G73]], [[2i3h|2I3H]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2opy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2opy OCA], [http://www.ebi.ac.uk/pdbsum/2opy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2opy RCSB]</span>
}}
}}


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==Overview==
==Overview==
A small series of peptide mimics was designed and synthesized to contain a heterocyclic ring in place of the potentially labile N-terminal peptide bond of the tetrapeptide containing the Smac-XIAP-binding motif. Two Smac mimics were shown to bind to the BIR3 domain of XIAP with moderate affinity and one displayed increased activity in cells relative to the Smac peptides. The structures of BIR3-XIAP in complex with a Smac peptide and a peptide mimic were solved and analyzed to elucidate the structure-activity relationship surrounding the Smac-binding domain within BIR3-XIAP.
A small series of peptide mimics was designed and synthesized to contain a heterocyclic ring in place of the potentially labile N-terminal peptide bond of the tetrapeptide containing the Smac-XIAP-binding motif. Two Smac mimics were shown to bind to the BIR3 domain of XIAP with moderate affinity and one displayed increased activity in cells relative to the Smac peptides. The structures of BIR3-XIAP in complex with a Smac peptide and a peptide mimic were solved and analyzed to elucidate the structure-activity relationship surrounding the Smac-binding domain within BIR3-XIAP.
==Disease==
Known diseases associated with this structure: Lymphoproliferative syndrome, X-linked, 2 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300079 300079]]


==About this Structure==
==About this Structure==
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[[Category: Shi, Y.]]
[[Category: Shi, Y.]]
[[Category: Wist, A D.]]
[[Category: Wist, A D.]]
[[Category: CO9]]
[[Category: ZN]]
[[Category: bir3]]
[[Category: bir3]]
[[Category: peptide mimic]]
[[Category: peptide mimic]]


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