5ysx: Difference between revisions
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==Structure of P domain of GII.2 Noroviruses== | |||
<StructureSection load='5ysx' size='340' side='right' caption='[[5ysx]], [[Resolution|resolution]] 1.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5ysx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YSX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YSX FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ysx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ysx OCA], [http://pdbe.org/5ysx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ysx RCSB], [http://www.ebi.ac.uk/pdbsum/5ysx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ysx ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Background: During 2016-2017, the previously rare GII.P16-GII.2 norovirus suddenly emerged as the predominant genotype causing gastroenteritis outbreaks in China and other countries. Its origin, phylodynamics, and mechanism behind the predominance remain unclear. Methods: Bayesian phylogenetic analyses were performed on 180 full capsid and 150 polymerase sequences of 2016-2017 GII.P16-GII.2 noroviruses in China, and those for all publicly available GII.P16 and GII.2 sequences. Saliva-based histo-blood group antigen (HBGA) binding assays and crystal structural analysis were conducted by using the P proteins of 2016-2017 GII.P16-GII.2 noroviruses. Results: The reemerging GII.P16-GII.2 norovirus showed a rapid genetic diversification after its emergence in 2012-2013. The antigenicity and HBGA binding profile of the early 2016-2017 and pre-2016 GII.2 noroviruses were similar. A further variant with a single Val256Ile mutation and the conventionally orientated Asp382 in the VP1 protein showed an expanded HBGA-binding spectrum. Mutations on the surface of polymerase that could alter its function were seen, which may help to accelerate the VP1 gene evolution to 5.5 x 10-3 substitutions per site per year. This virus can be traced back to Pearl River Delta, China. Conclusions: Our findings provide new insights into GII.2 norovirus epidemics and highlight the necessity of enhanced global surveillance for potential epidemics of rare-genotype noroviruses. | |||
Genetic Analysis of Reemerging GII.P16-GII.2 Noroviruses in 2016-2017 in China.,Ao Y, Cong X, Jin M, Sun X, Wei X, Wang J, Zhang Q, Song J, Yu J, Cui J, Qi J, Tan M, Duan Z J Infect Dis. 2018 Jun 5;218(1):133-143. doi: 10.1093/infdis/jiy182. PMID:29617875<ref>PMID:29617875</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 5ysx" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Ao, Y]] | |||
[[Category: Duan, Z]] | |||
[[Category: Cell adhesion]] | |||
[[Category: Gii 2 noroviruse]] | |||
[[Category: P dimer]] | |||
Revision as of 21:43, 9 August 2018
Structure of P domain of GII.2 Noroviruses
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