6h00: Difference between revisions

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'''Unreleased structure'''


The entry 6h00 is ON HOLD
==Crystal structure of human pyridoxine 5-phophate oxidase, R116Q variant==
 
<StructureSection load='6h00' size='340' side='right' caption='[[6h00]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
Authors: Mackinnon, S., Wilson, M.P., Shrestha, L., Bezerra, G.A., Newman, J., Fox, N., Sorrell, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Clayton, P.T., Mills, P.B., Yue, W.W.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6h00]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H00 FirstGlance]. <br>
Description: Crystal structure of human pyridoxine 5-phophate oxidase, R116Q variant
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyridoxal_5'-phosphate_synthase Pyridoxal 5'-phosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.5 1.4.3.5] </span></td></tr>
[[Category: Yue, W.W]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h00 OCA], [http://pdbe.org/6h00 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h00 RCSB], [http://www.ebi.ac.uk/pdbsum/6h00 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h00 ProSAT]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/PNPO_HUMAN PNPO_HUMAN]] Defects in PNPO are the cause of pyridoxine-5'-phosphate oxidase deficiency (PNPO deficiency) [MIM:[http://omim.org/entry/610090 610090]]; also known as PNPO-related neonatal epileptic encephalopathy. The main feature of neonatal epileptic encephalopathy is the onset within hours of birth of a severe seizure disorder that does not respond to anticonvulsant drugs and can be fatal. Seizures can cease with the administration of PLP, being resistant to treatment with pyridoxine.
== Function ==
[[http://www.uniprot.org/uniprot/PNPO_HUMAN PNPO_HUMAN]] Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).<ref>PMID:12824491</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Pyridoxal 5'-phosphate synthase]]
[[Category: Arrowsmith, C H]]
[[Category: Bezerra, G A]]
[[Category: Bountra, C]]
[[Category: Clayton, P T]]
[[Category: Edwards, A]]
[[Category: Fox, N]]
[[Category: Mackinnon, S]]
[[Category: Mackinnon, S]]
[[Category: Mills, P B]]
[[Category: Newman, J]]
[[Category: Newman, J]]
[[Category: Clayton, P.T]]
[[Category: Bountra, C]]
[[Category: Wilson, M.P]]
[[Category: Fox, N]]
[[Category: Arrowsmith, C.H]]
[[Category: Shrestha, L]]
[[Category: Shrestha, L]]
[[Category: Bezerra, G.A]]
[[Category: Edwards, A]]
[[Category: Mills, P.B]]
[[Category: Sorrell, F]]
[[Category: Sorrell, F]]
[[Category: Wilson, M P]]
[[Category: Yue, W W]]
[[Category: Fmn-binding]]
[[Category: Oxidoreductase]]
[[Category: Pnp-oxidase activity]]
[[Category: Pnpo]]
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