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| <StructureSection load='1xng' size='450' side='right' caption='NAD+ synthase complex with Mg+2 (green), ATP and deamino-NAD (PDB entry [[1xng]])' scene='54/541072/Cv/1'> | | <StructureSection load='1xng' size='350' side='right' caption='NAD+ synthase complex with Mg+2 (green), ATP and deamino-NAD (PDB entry [[1xng]])' scene='54/541072/Cv/1'> |
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| == Function == | | == Function == |
Revision as of 09:11, 12 August 2018
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Function
NAD+ synthase (NADS) catalyzes the conversion of ATP, deamino-NAD+ and NH3 to AMP, NAD+ and diphosphate (PP). NADS is part of the NAD synthesis pathway[1] . See NAD.
Structural highlights
The ATP binding site contains Mg+2 ion. The NAD binding site is located in the interface of the 2 subunits[2]. Water molecules shown as red spheres.
- ↑ Suda Y, Tachikawa H, Yokota A, Nakanishi H, Yamashita N, Miura Y, Takahashi N. Saccharomyces cerevisiae QNS1 codes for NAD(+) synthetase that is functionally conserved in mammals. Yeast. 2003 Aug;20(11):995-1005. PMID:12898714 doi:https://dx.doi.org/10.1002/yea.1008
- ↑ Kang GB, Kim YS, Im YJ, Rho SH, Lee JH, Eom SH. Crystal structure of NH3-dependent NAD+ synthetase from Helicobacter pylori. Proteins. 2005 Mar 1;58(4):985-8. PMID:15645437 doi:10.1002/prot.20377
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3D Structures of NAD+ synthase
Updated on 12-August-2018
{"openlevels":0}
- NAD synthase
- NAD – NADS – Campylobacter jejuni
- 3q4g – NADS (mutant) – Vibrio cholerae
- 1wxf – EcNADS – Escherichia coli
- 1xnh – HpNADS - Helicobacter pylori
- 2pzb – BaNADS - Bacillus anthracis
- 3dpi – NADS – Burkholderia pseudomallei
- NADS binary complex
- 1ifx – BsNADS + deamino-NAD – Bacillus subtilis
- 1wxh – EcNADS + NAD
- 3hmq – BsNADS + NAD – Salmonella typhimurium
- NADS ternary complex
- 1ih8 – BsNADS + Mg + ATP derivative
- 1wxe – EcNADS + Mg + AMP
- 1wxg – EcNADS + Mg + deamino-NAD
- 2pz8 – BaNADS + Mg + ATP derivative
- NADS quaternary complex
- 1ee1 – BsNADS + Mg + ATP + deamino-NAD
- 1fyd – BsNADS + Mg + AMP + PP
- 1kqp – BsNADS + Mg + PP + NAD derivative
- 1wxi – EcNADS + Mg + AMP + PP
- 1xng – HpNADS + Mg + ATP + deamino-NAD
- 2pza – BaNADS + Mg + AMP + PP
- NADS quinary complex
- 1nsy – BsNADS + Mg + ATP + ADP + PP
- 2nsy – BsNADS + Mg + AMP + NAD + PP
- NADS glutamine-dependent
- 3sdb – MtNADS (mutant) – Mycobacterium tuberculosis
- 3seq, 3sez – MtNADS (mutant) + ATP derivative + pyridinium derivative
- 3szg – MtNADS (mutant) + AMP + pyridinium derivative
- 3syt – MtNADS + AMP + NAD + glutamate
References
