Netrin: Difference between revisions
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<StructureSection load='4ove' size=' | <StructureSection load='4ove' size='350' side='right' caption='Glycosylated mouse netrin-1 complex with Ca+2 and Cl-1 ions (PDB code [[4ove]])' scene='' pspeed='8'> | ||
== Function == | == Function == | ||
'''Netrins''' (Net) direct cell and axon migration during development. Netrins are chemotropic. The growing axon moves either toward or away from netrin concentration. Netrins influence the formation of a variety of tissues. They act as chemoattractants for some cell types and chemorepellent for other types<ref>PMID:18269208</ref>. '''Netrin-1''' is a secreted protein while '''netrin-G2''' is GPI-anchored membrane protein. | '''Netrins''' (Net) direct cell and axon migration during development. Netrins are chemotropic. The growing axon moves either toward or away from netrin concentration. Netrins influence the formation of a variety of tissues. They act as chemoattractants for some cell types and chemorepellent for other types<ref>PMID:18269208</ref>. '''Netrin-1''' is a secreted protein while '''netrin-G2''' is GPI-anchored membrane protein. | ||
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**[[4plo]] – cNet1 LN-LE3 domains + mNet receptor DCC fourth fibronectin type IV-V domains <BR /> | **[[4plo]] – cNet1 LN-LE3 domains + mNet receptor DCC fourth fibronectin type IV-V domains <BR /> | ||
**[[4urt]] – hNet1 LN-LE3 domains + hNet receptor DCC fourth fibronectin type V-VI domains - human<BR /> | **[[4urt]] – hNet1 LN-LE3 domains + hNet receptor DCC fourth fibronectin type V-VI domains - human<BR /> | ||
**[[6fkq]] – hNet1 LN-LE3 domains + draxin peptide<BR /> | |||
*Netrin-4 | *Netrin-4 | ||
