5nv1: Difference between revisions
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==SH3 domain from Mouse cortactin (C 2 2 21 crystal form)== | |||
<StructureSection load='5nv1' size='340' side='right' caption='[[5nv1]], [[Resolution|resolution]] 1.51Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5nv1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NV1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NV1 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nv1 OCA], [http://pdbe.org/5nv1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nv1 RCSB], [http://www.ebi.ac.uk/pdbsum/5nv1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nv1 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/SRC8_MOUSE SRC8_MOUSE]] Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.<ref>PMID:17403031</ref> <ref>PMID:22262902</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Dessau, M]] | |||
[[Category: Twafra, S]] | [[Category: Twafra, S]] | ||
[[Category: | [[Category: Cancer]] | ||
[[Category: Cortactin]] | |||
[[Category: Invadopodium]] | |||
[[Category: Sh3 domain]] | |||
[[Category: Signaling]] | |||
[[Category: Signaling protein]] | |||
Revision as of 16:06, 15 August 2018
SH3 domain from Mouse cortactin (C 2 2 21 crystal form)
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