5nvj: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5nvj is ~~ON HOLD until Paper Publication~~

==SH3 domain from Mouse cortactin (C 1 2 1 crystal form)==

~~Authors~~: ~~Twafra~~, S., ~~Dessau~~, M.

== Structural highlights ==

<table><tr><td colspan='2'>[[5nvj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NVJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NVJ FirstGlance]. <br>

~~Description~~: ~~SH3 domain from Mouse cortactin~~ (~~C 1 2 1 crystal form~~)

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BAM:BENZAMIDINE'>BAM</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nvj OCA], [http://pdbe.org/5nvj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nvj RCSB], [http://www.ebi.ac.uk/pdbsum/5nvj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nvj ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/SRC8_MOUSE SRC8_MOUSE]] Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.<ref>PMID:17403031</ref> <ref>PMID:22262902</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Dessau, M]]

[[Category: Twafra, S]]

[[Category: ~~Dessau, M~~]]

[[Category: Cancer]]

[[Category: Cortactin]]

[[Category: Invadopodium]]

[[Category: Sh3 domain]]

[[Category: Signaling]]

[[Category: Signaling protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5nvj is ON HOLD  until Paper Publication
+==SH3 domain from Mouse cortactin (C 1 2 1 crystal form)==
+<StructureSection load='5nvj' size='340' side='right' caption='[[5nvj]], [[Resolution|resolution]] 1.18&Aring;' scene=''>
-Authors: Twafra, S., Dessau, M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5nvj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NVJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NVJ FirstGlance]. <br>
-Description: SH3 domain from Mouse cortactin (C 1 2 1 crystal form)
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BAM:BENZAMIDINE'>BAM</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nvj OCA], [http://pdbe.org/5nvj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nvj RCSB], [http://www.ebi.ac.uk/pdbsum/5nvj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nvj ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/SRC8_MOUSE SRC8_MOUSE]] Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.<ref>PMID:17403031</ref> <ref>PMID:22262902</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Dessau, M]]
 [[Category: Twafra, S]]
-[[Category: Dessau, M]]
+[[Category: Cancer]]
+[[Category: Cortactin]]
+[[Category: Invadopodium]]
+[[Category: Sh3 domain]]
+[[Category: Signaling]]
+[[Category: Signaling protein]]