6gun: Difference between revisions
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==Siderophore hydrolase EstB from Aspergillus nidulans== | |||
<StructureSection load='6gun' size='340' side='right' caption='[[6gun]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6gun]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GUN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GUN FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gun OCA], [http://pdbe.org/6gun PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gun RCSB], [http://www.ebi.ac.uk/pdbsum/6gun PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gun ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Fungi utilize high-affinity chelators termed siderophores with chemically diverse structures to scavenge the essential nutrient iron from their surroundings. As they are among the strongest known Fe3+ binding agents, intracellular release of the heavy metal atom is facilitated by the activity of specific hydrolases. In this work, we report the characterization and x-ray structures of four siderophore esterases, AfEstB and AfSidJ from Aspergillus fumigatus, as well as AnEstB and AnEstA from Aspergillus nidulans. Even though they all display the conserved alpha/beta-hydrolase fold, we found remarkable structural and enzymatic discrepancies in their adaption to both related and chemically diverse substrates. A complex structure of AfEstB and its substrate triacetylfusarinine C gives insights into an active enzyme, with a tetrahedral coordination between the catalytic serine and the scissile ester bond. | |||
Iron scavenging in Aspergillus species: Structural and biochemical insights into fungal siderophore esterases.,Ecker F, Haas H, Groll M, Huber E Angew Chem Int Ed Engl. 2018 Aug 1. doi: 10.1002/anie.201807093. PMID:30070018<ref>PMID:30070018</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6gun" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Ecker, F]] | |||
[[Category: Groll, M]] | |||
[[Category: Haas, H]] | |||
[[Category: Huber, E M]] | |||
[[Category: Alpha/beta-hydrolase]] | |||
[[Category: Fungi]] | |||
[[Category: Hydrolase]] | |||
[[Category: Hydrolysis]] | |||
[[Category: Siderophore]] | |||
Revision as of 16:24, 15 August 2018
Siderophore hydrolase EstB from Aspergillus nidulans
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