6aoh: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 6aoh is ON HOLD until Paper Publication~~

==Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-(3-(2-methoxypyrimidin-5-yl)phenyl)piperazin-1-yl)pyrimidine-2,4-diamine (TRC-2533)==

~~Authors: Thomas, S.B., Li, Y., Chen, Z., Lu, H.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[6aoh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AOH OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AOH FirstGlance].

~~Description:~~ Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-(3-(2-methoxypyrimidin-5-yl)phenyl)piperazin-1-yl)pyrimidine-2,4-diamine (TRC-2533)

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=BOD:5-{4-[3-(2-methoxypyrimidin-5-yl)phenyl]piperazin-1-yl}pyrimidine-2,4-diamine'>BOD</scene>, <scene name='pdbligand=CB3:10-PROPARGYL-5,8-DIDEAZAFOLIC+ACID'>CB3</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[6aog|6aog]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6aoh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aoh OCA], [http://pdbe.org/6aoh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aoh RCSB], [http://www.ebi.ac.uk/pdbsum/6aoh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aoh ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/DRTS_TOXGO DRTS_TOXGO]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity).

__TOC__

</StructureSection>

[[Category: Chen, Z]]

[[Category: Li, Y]]

[[Category: Lu, H]]

[[Category: ~~Chen~~, Z]]

[[Category: Thomas, S B]]

[[Category: ~~Thomas, S.B~~]]

[[Category: Dhfr]]

[[Category: Oxidoreductase]]

[[Category: Pyrimethamine]]

[[Category: Toxoplasma gondii]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6aoh is ON HOLD  until Paper Publication
+==Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-(3-(2-methoxypyrimidin-5-yl)phenyl)piperazin-1-yl)pyrimidine-2,4-diamine (TRC-2533)==
+<StructureSection load='6aoh' size='340' side='right' caption='[[6aoh]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
-Authors: Thomas, S.B., Li, Y., Chen, Z., Lu, H.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6aoh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AOH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AOH FirstGlance]. <br>
-Description: Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-(3-(2-methoxypyrimidin-5-yl)phenyl)piperazin-1-yl)pyrimidine-2,4-diamine (TRC-2533)
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOD:5-{4-[3-(2-methoxypyrimidin-5-yl)phenyl]piperazin-1-yl}pyrimidine-2,4-diamine'>BOD</scene>, <scene name='pdbligand=CB3:10-PROPARGYL-5,8-DIDEAZAFOLIC+ACID'>CB3</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6aog|6aog]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6aoh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aoh OCA], [http://pdbe.org/6aoh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aoh RCSB], [http://www.ebi.ac.uk/pdbsum/6aoh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aoh ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/DRTS_TOXGO DRTS_TOXGO]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Chen, Z]]
 [[Category: Li, Y]]
 [[Category: Lu, H]]
-[[Category: Chen, Z]]
+[[Category: Thomas, S B]]
-[[Category: Thomas, S.B]]
+[[Category: Dhfr]]
+[[Category: Oxidoreductase]]
+[[Category: Pyrimethamine]]
+[[Category: Toxoplasma gondii]]