6ar4: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "6ar4" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
==Crystal structure of PICK1 in complex with the small molecule inhibitor 31596== | |||
<StructureSection load='6ar4' size='340' side='right' caption='[[6ar4]], [[Resolution|resolution]] 1.69Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6ar4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AR4 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BQA:N-[4-(4-bromophenyl)-1-{[2-(trifluoromethyl)phenyl]methyl}piperidine-4-carbonyl]-3-cyclopropyl-L-alanine'>BQA</scene></td></tr> | |||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ar4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ar4 OCA], [http://pdbe.org/6ar4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ar4 RCSB], [http://www.ebi.ac.uk/pdbsum/6ar4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ar4 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PICK1_HUMAN PICK1_HUMAN]] Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ASIC1/ASIC3 channel.<ref>PMID:20403402</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Marcotte, D]] | [[Category: Marcotte, D]] | ||
[[Category: Actin binding protein]] | |||
[[Category: Pdz domain pdz inhibitor]] | |||
