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'''Unreleased structure'''


The entry 6dvm is ON HOLD  until Paper Publication
==Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with DDK-122==
<StructureSection load='6dvm' size='340' side='right' caption='[[6dvm]], [[Resolution|resolution]] 1.47&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6dvm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DVM FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HBJ:4-(dimethylamino)-N-{[4-(hydroxycarbamoyl)phenyl]methyl}-N-{2-[(4-methylphenyl)amino]-2-oxoethyl}benzamide'>HBJ</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dvm OCA], [http://pdbe.org/6dvm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dvm RCSB], [http://www.ebi.ac.uk/pdbsum/6dvm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dvm ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Four crystal structures are presented of histone deacetylase 6 (HDAC6) complexes with para-substituted phenylhydromaxamate inhibitors, including bulky peptoids. These structures provide insight regarding the design of capping groups that confer selectivity for binding to HDAC6, specifically with regard to interactions in a pocket formed by the L1 loop. Capping group interactions may also influence hydroxamate-Zn(2+) coordination with monodentate or bidentate geometry.


Authors: Porter, N.J., Christianson, D.W.
Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity.,Porter NJ, Osko JD, Diedrich D, Kurz T, Hooker JM, Hansen FK, Christianson DW J Med Chem. 2018 Aug 17. doi: 10.1021/acs.jmedchem.8b01013. PMID:30118224<ref>PMID:30118224</ref>


Description: Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with DDK-122
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Christianson, D.W]]
<div class="pdbe-citations 6dvm" style="background-color:#fffaf0;"></div>
[[Category: Porter, N.J]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Christianson, D W]]
[[Category: Porter, N J]]
[[Category: Histone deacetylaase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Metallohydrolase]]
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