Cruzain: Difference between revisions
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<StructureSection load='1me3' size='350' side='right' caption='Structure of cruzain catalytic domain complex with methylketone inhibitor (PDB entry [[1me3]])' scene='51/517378/Cv/1'> | <StructureSection load='1me3' size='350' side='right' caption='Structure of cruzain catalytic domain complex with methylketone inhibitor (PDB entry [[1me3]])' scene='51/517378/Cv/1'> | ||
'''Cruzain''' (Cru) is the major cysteine protease present in ''Trypanosoma cruzi'' which is the parasite causing Chagas disease. <ref>PMID:10997902</ref> | '''Cruzain''' or '''cruzapain''' (Cru) is the major cysteine protease present in ''Trypanosoma cruzi'' which is the parasite causing Chagas disease. <ref>PMID:10997902</ref> | ||
== Relevance == | == Relevance == | ||
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[[1ewl]], [[1ewm]] – Cru catalytic domain + methylbutane inhibitor<br /> | [[1ewl]], [[1ewm]] – Cru catalytic domain + methylbutane inhibitor<br /> | ||
[[1ewp]] - Cru catalytic domain + MOR-Leu-HPQ<br /> | [[1ewp]] - Cru catalytic domain + MOR-Leu-HPQ<br /> | ||
[[4w5b]], [[4xui]], [[4qh6]], [[4pi3]], [[4klb]], [[3lxs]], [[3kku]], [[3i06]], [[2oz2]], [[1u9q]] – TcPRO + inhibitor <br /> | |||
[[4w5c]], [[3iut]], [[3hd3]] – TcPRO (mutant) + inhibitor <br /> | |||
== References == | == References == | ||
<references/> | <references/> | ||
