Retroviral Integrase: Difference between revisions
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*Human spumaretrovirus integrase | *Human spumaretrovirus integrase | ||
**[[3os0]], [[3os1]], [[3os2]], [[3oy9]], [[3l2q]], [[3l2r]], [[4e7j]], [[4e7k]], [[4e7l]] – IN + DNA – human spumaretrovirus<br /> | **[[3os0]], [[3os1]], [[3os2]], [[3oy9]], [[3l2q]], [[3l2r]], [[4e7j]], [[4e7k]], [[4e7l]], [[5uoq]], [[5uop]], [[5no1]], [[5mmb]], [[5mma]], [[5fro]], [[5frm]], [[4ztj]], [[4ztf]] – IN + DNA – human spumaretrovirus<br /> | ||
**[[3oyb]], [[3oyc]], [[3oyd]], [[3oye]], [[3oyf]], [[3oyg]], [[3oyh]], [[3oyi]], [[3oyj]], [[3oyk]], [[3oyl]], [[3oym]], [[3oyn]], [[3oya]], [[3l2u]], [[3l2v]], [[3l2w]] – IN + DNA + inhibitor<br /> | **[[3oyb]], [[3oyc]], [[3oyd]], [[3oye]], [[3oyf]], [[3oyg]], [[3oyh]], [[3oyi]], [[3oyj]], [[3oyk]], [[3oyl]], [[3oym]], [[3oyn]], [[3oya]], [[3l2u]], [[3l2v]], [[3l2w]] – IN + DNA + inhibitor<br /> | ||
**[[2x6n]], [[2x6s]], [[2x74]], [[2x78]], [[3dlr]] - IN catalytic core domain | **[[2x6n]], [[2x6s]], [[2x74]], [[2x78]], [[3dlr]] - IN catalytic core domain | ||
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*Human immunodeficiency virus 1 integrase | *Human immunodeficiency virus 1 integrase | ||
**[[3lpt]], [[3lpu]], [[3l3u]], [[1exq]], [[1b92]], [[1b9d]], [[1b9f]], [[1bi4]], [[1bhl]], [[1bl3]], [[1bis]], [[1biu]], [[1biz]], [[2itg]], [[3zcm]] - IN catalytic core domain (mutant) – HIV-1<br /> | **[[5oi5]], [[5oi3]], [[5oi2]], [[1itg]] – IN catalytic core domain <br /> | ||
**[[3lpt]], [[3lpu]], [[3l3u]], [[1exq]], [[1b92]], [[1b9d]], [[1b9f]], [[1bi4]], [[1bhl]], [[1bl3]], [[1bis]], [[1biu]], [[1biz]], [[2itg]], [[3zcm]], [[5jl4]] - IN catalytic core domain (mutant) – HIV-1<br /> | |||
**[[3l3v ]]- IN catalytic core domain (mutant) + sucrose<br /> | **[[3l3v ]]- IN catalytic core domain (mutant) + sucrose<br /> | ||
**[[1hyv]], [[1hyz]], [[1qs4]] - IN N-terminal + inhibitor<br /> | **[[1hyv]], [[1hyz]], [[1qs4]] - IN N-terminal + inhibitor<br /> | ||
**[[1k6y]] - IN N-terminal + catalytic core domain<br /> | **[[1k6y]] - IN N-terminal + catalytic core domain<br /> | ||
**[[1wje]], [[1wjf]] - IN N-terminal zinc-binding domain (mutant) – NMR<br /> | **[[1wje]], [[1wjf]] - IN N-terminal zinc-binding domain (mutant) – NMR<br /> | ||
**[[1wja]], [[1wjb]], [[1wjc]], [[1wjd]] - IN N-terminal zinc-binding domain<br /> | **[[1wja]], [[1wjb]], [[1wjc]], [[1wjd]] - IN N-terminal zinc-binding domain<br /> | ||
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**[[1qmc]] – IN DBD - NMR<br /> | **[[1qmc]] – IN DBD - NMR<br /> | ||
**[[2b4j]], [[3av9]], [[3ava]], [[3avb]], [[3avc]], [[3avf]], [[3avg]], [[3avh]], [[3avi]], [[3avj]], [[3avk]], [[3avl]], [[3avm]], [[3avn]] - IN (mutant) + lens epithelium-derived growth factor <br /> | **[[2b4j]], [[3av9]], [[3ava]], [[3avb]], [[3avc]], [[3avf]], [[3avg]], [[3avh]], [[3avi]], [[3avj]], [[3avk]], [[3avl]], [[3avm]], [[3avn]] - IN (mutant) + lens epithelium-derived growth factor <br /> | ||
**[[3nf6]], [[3nf7]], [[3nf8]], [[3nf9]], [[3nfa]], [[4e1m]], [[4e1n]], [[4cj4]], [[4jlh]], [[4ojr]] - IN core domain (mutant) + inhibitor<br /> | **[[6ex9]], [[5krt]], [[5krs]], [[5kgx]], [[5kgw]], [[4o0j]] – IN catalytic core domain + inhibitor <br /> | ||
**[[3nf6]], [[3nf7]], [[3nf8]], [[3nf9]], [[3nfa]], [[4e1m]], [[4e1n]], [[4cj4]], [[4jlh]], [[4ojr]], [[5hrs]], [[5hrr]], [[5hrp]], [[5hrn]], [[5hot]], [[4tsx]], [[4ovl]], [[4ojr]], [[4o5b]], [[4o55]], [[4nyf]] - IN core domain (mutant) + inhibitor<br /> | |||
**[[5tc2]] – IN C terminal <br /> | |||
**[[5eu7]] – IN catalytic core domain + antibody <br /> | |||
**[[4y1d]], [[4y1c]] – IN catalytic core domain + peptide <br /> | |||
*Human immunodeficiency virus 2 integrase | *Human immunodeficiency virus 2 integrase | ||
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*Maedi Visna virus integrase | *Maedi Visna virus integrase | ||
**[[3hpg]], [[3hph]] – IN N-terminal + catalytic core domain + LEDGF IBD – MVV | **[[3hpg]], [[3hph]] – IN N-terminal + catalytic core domain + LEDGF IBD – MVV<br /> | ||
**[[5t3a]] – IN <br /> | |||
**[[5llj]] – IN C terminal<br /> | |||
**[[5m0r]], [[5m0q]] – IN + DNA – Cryo EM<br /> | |||
*Simian immunodeficiency virus integrase | *Simian immunodeficiency virus integrase | ||
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*Feline immunodeficiency virus integrase | *Feline immunodeficiency virus integrase | ||
**[[4pa1]] | **[[4pa1]] - IN catalytic core domain - FIV<br /> | ||
**[[4mq3]] – IN catalytic core domain (mutant)<br /> | |||
*Mouse mammary tumor virus | |||
**[[5cz1]] – IN catalytic domain <br /> | |||
*Rous sarcoma virus integrase | *Rous sarcoma virus integrase | ||
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**[[1vsk]], [[1vsl]], [[3o4q]] - IN catalytic core domain (mutant)<br /> | **[[1vsk]], [[1vsl]], [[3o4q]] - IN catalytic core domain (mutant)<br /> | ||
**[[1vsm]], [[1vsh]], [[1vsi]], [[1vsj]], [[1vsd]], [[1vse]], [[1vsf]], [[3o4n]] - IN catalytic core domain<br /> | **[[1vsm]], [[1vsh]], [[1vsi]], [[1vsj]], [[1vsd]], [[1vse]], [[1vsf]], [[3o4n]] - IN catalytic core domain<br /> | ||
**[[1a5v]], [[1a5w]], [[1a5x]] - IN catalytic core domain + inhibitor | **[[1a5v]], [[1a5w]], [[1a5x]] - IN catalytic core domain + inhibitor<br /> | ||
**[[5ejk]] – IN + DNA + gag-pro-pol polyprotein <br /> | |||
*Avian sarcoma virus integrase | *Avian sarcoma virus integrase | ||
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**[[3nkh]] – IN fragment – ''Staphylococcus aureus'' MRSA<br /> | **[[3nkh]] – IN fragment – ''Staphylococcus aureus'' MRSA<br /> | ||
**[[1b69]], [[1tn9]] - EfIN N-terminal DBD + DNA – ''Enterococcus faecalis'' – NMR<br /> | **[[1b69]], [[1tn9]] - EfIN N-terminal DBD + DNA – ''Enterococcus faecalis'' – NMR<br /> | ||
**[[1bb8]], [[2bb8]] - EfIN N-terminal DBD – NMR | **[[1bb8]], [[2bb8]] - EfIN N-terminal DBD – NMR<br /> | ||
**[[3nrw]] – IN/site-specific recombinase N-terminal – ''Haloarcula marismortui''<br /> | |||
**[[3jtz]] – IN arm-type binding domain – ''Yersinia pestis''<br /> | |||
**[[3ju0]] – HPI IN arm-type binding domain – ''Pectobacterium atrosepticum''<br /> | |||
**[[2kkp]] – IN SAM-like domain – ''Moorella thermoacetica'' – NMR<br /> | |||
**[[2kkv]] – IN fragment – ''Salmonella enterica'' – NMR<br /> | |||
**[[2khq]] - IN fragment – ''Staphylococcus saprophyticus'' – NMR<br /> | |||
**[[2khv]], [[2kj5]] – INT residues 102-199 – ''Nitrosospira multiformis'' – NMR<br /> | |||
**[[2a3v]] – Rec INTI4+DNA – ''Vibrio cholera''<br /> | |||
**[[1z19]], [[1z1b]], [[1z1g]], [[1p7d]] – EpLamInt catalytic core domain+DNA<br /> | |||
**[[6emy]], [[6emz]], [[6en0]], [[6en1]], [[6en2]] – IN (mutant) + DNA – Enterococcus faecalis<br /> | |||
*Phage integrase | |||
**[[3bvp]] – Integrase N-terminal – Lactococcus phage <br /> | |||
**[[1aih]] – HP1 integrase catalytic domain – bacteriophage<br /> | |||
**[[5dor]], [[5c6k]] – IN catalytic domain – Enterobacteria phage P2 <br /> | |||
**[[2wcc]], [[1kjk]] – λIN DBD+ DNA – Enterobacteria phage λ - NMR<br /> | |||
**[[2oxo]] – λIN residues 75-176<br /> | |||
**[[1ae9]] – λIN catalytic core<br /> | |||
**[[5j0n]] – λIN + ATTP + ATTB + integration host factor + excisionase - Cryo EM<br /> | |||
*Yeast integrase | |||
**[[1p4e]], 1m6x]] – FLP (mutant)+DNA <br /> | |||
**[[1flo]] - FLP +DNA<br /> | |||
}} | }} | ||
