5otm: Difference between revisions
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==Crystal structure of human MTH1 in complex with O6-methyl-dGMP== | |||
<StructureSection load='5otm' size='340' side='right' caption='[[5otm]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5otm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OTM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OTM FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6OG:6-O-METHYL+GUANOSINE-5-MONOPHOSPHATE'>6OG</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5otm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5otm OCA], [http://pdbe.org/5otm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5otm RCSB], [http://www.ebi.ac.uk/pdbsum/5otm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5otm ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Berglund, U Warpman]] | |||
[[Category: Brautigam, L]] | |||
[[Category: Gustafsson, R]] | |||
[[Category: Helleday, T]] | |||
[[Category: Henriksson, L]] | |||
[[Category: Homan, E]] | |||
[[Category: Jemth, A S]] | |||
[[Category: Puigvert, J Carreras]] | |||
[[Category: Stenmark, P]] | |||
[[Category: Complex]] | |||
[[Category: Hydrolase]] | |||
[[Category: Inhibitor]] | |||
[[Category: Methylated nucleotide]] | |||
[[Category: Mth1]] | |||
[[Category: Nudix]] | |||
[[Category: O6-methyl-dgmp]] | |||
Revision as of 09:58, 5 September 2018
Crystal structure of human MTH1 in complex with O6-methyl-dGMP
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