5yaw: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 5yaw is ON HOLD until Sep 01 2019~~

==Fragment-based Drug Discovery of inhibitors to block PDEdelta-RAS protein-protein interaction==

~~Authors: Bing, X., Yanlian, L., Danyan, C.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5yaw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YAW FirstGlance]. <br>

~~Description:~~ Fragment-based Drug Discovery of inhibitors to block PDEdelta-RAS protein-protein interaction

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8SL:3-[(4-methoxyphenyl)methylsulfanyl]-5-(2-methylpropyl)-4-(phenylmethyl)-1,2,4-triazole'>8SL</scene></td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yaw OCA], [http://pdbe.org/5yaw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yaw RCSB], [http://www.ebi.ac.uk/pdbsum/5yaw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yaw ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN]] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity).

__TOC__

</StructureSection>

[[Category: Bing, X]]

[[Category: Danyan, C]]

[[Category: Yanlian, L]]

[[Category: Oncoprotein]]

[[Category: Pde6]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5yaw is ON HOLD  until Sep 01 2019
+==Fragment-based Drug Discovery of inhibitors to block PDEdelta-RAS protein-protein interaction==
+<StructureSection load='5yaw' size='340' side='right' caption='[[5yaw]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
-Authors: Bing, X., Yanlian, L., Danyan, C.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5yaw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YAW FirstGlance]. <br>
-Description: Fragment-based Drug Discovery of inhibitors to block PDEdelta-RAS protein-protein interaction
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8SL:3-[(4-methoxyphenyl)methylsulfanyl]-5-(2-methylpropyl)-4-(phenylmethyl)-1,2,4-triazole'>8SL</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yaw OCA], [http://pdbe.org/5yaw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yaw RCSB], [http://www.ebi.ac.uk/pdbsum/5yaw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yaw ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN]] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity).
+__TOC__
+</StructureSection>
 [[Category: Bing, X]]
 [[Category: Danyan, C]]
 [[Category: Yanlian, L]]
+[[Category: Oncoprotein]]
+[[Category: Pde6]]